Evidence map›Paper›PMID 35854214›Full record

ArticleBMC pregnancy and childbirth2022

Incidence and risk factors for early pregnancy loss in women with first pregnancy undergoing in vitro fertilization-embryo transfer.

Mohan Wang, Xiao Yang, Linlin Li, Haibo Zhu, Hongguo Zhang, Yuting Jiang, Ruizhi Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mohan WangCenter of Reproductive Medicine and Center of Prenatal Diagnosis, the First Hospital, Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021, China.
Xiao YangCenter of Reproductive Medicine and Center of Prenatal Diagnosis, the First Hospital, Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021, China.
Linlin LiCenter of Reproductive Medicine and Center of Prenatal Diagnosis, the First Hospital, Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021, China.
Haibo ZhuCenter of Reproductive Medicine and Center of Prenatal Diagnosis, the First Hospital, Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021, China.
Hongguo ZhangCenter of Reproductive Medicine and Center of Prenatal Diagnosis, the First Hospital, Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021, China.
Yuting JiangCenter of Reproductive Medicine and Center of Prenatal Diagnosis, the First Hospital, Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021, China.
Ruizhi LiuCenter of Reproductive Medicine and Center of Prenatal Diagnosis, the First Hospital, Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021, China. liurz@jlu.edu.cn.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to explore the incidence and influencing factors for early pregnancy loss (EPL) in infertility patients with first pregnancy undergoing in vitro fertilization (IVF) embryo transfer cycles in Jilin province, China.

methodsA retrospective study of 2709 first pregnancy embryo transfer cycles collected from January 2016 to January 2021 was performed. The cycles were divided into the EPL group (n = 411) and the live birth group (n = 2298) according to the cycle outcomes.

resultsThe EPL rate of the first-time pregnancies for infertility patients undergoing fresh/frozen-thaw embryo transfer cycle was 14.1%. Female patients aged 40 and older had increased odds of EPL compared to those under 35 (OR = 3.97, 95%CI: 2.80-7.55). Female patients with a body mass index (BMI) of 25 or greater were more likely to have EPLs than those in the normal BMI range (OR = 1.32, 95%CI: 1.03-1.70). The odds of EPL after frozen-thaw embryo transfer were higher than those after fresh embryo transfer (OR = 1.59, 95%CI: 1.11-2.27). A thin endometrium on the day of embryo transfer increased the odds of EPL (OR = 1.84, 95%CI: 1.01-3.33). Transferring more than two embryos had lower odds of EPL than single-embryo transfer (OR = 0.67, 95%CI: 0.50-0.90). Compared with other infertility diagnoses, tubal factor alone was associated with lower odds of EPL (OR = 0.72, 95%CI: 0.53-0.98).

conclusionsThe risk factors for EPL were age 40 and older, obesity, frozen-thaw cycle, thin endometrium, and non-isolated tubal factor.

Indexed as

Abortion, SpontaneousInfertilityAdultEmbryo TransferFemaleFertilization in VitroHumansIncidenceLive BirthMiddle AgedPregnancyPregnancy RateRetrospective StudiesRisk FactorsEarly pregnancy lossInfertilityIn vitro fertilizationMiscarriage

Identifiers

PMID35854214
PMCPMC9295353
OpenAlexW4286219921

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.