Evidence map›Paper›PMID 35854172›Full record

ArticleActa neurologica Belgica2023

Association of white matter hyperintensities with migraine phenotypes and response to treatment.

Sherihan Rezk Ahmed, Amr Abdel Monem Mohamed, Haitham Hamdy Salem, Shahinaz Helmy, Ramez Reda Moustafa, Sherien Mohamed Farag Borham

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurologica Belgica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06058884 (Predictors of the Unfavourable Outcomes in Acute Ischemic Stroke Patients Treated With Alteplase, a Multi-centre Prospective Study), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06058884 phase4completednot on this map

Predictors of the Unfavourable Outcomes in Acute Ischemic Stroke Patients Treated With Alteplase, a Multi-centre Prospective Study

TypeinterventionalSponsorKafrelsheikh UniversityRan2022 to 2023Enrolled592ConditionsIschemic Stroke, Alteplase Adverse ReactionArmsAlteplase
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. A novel missense variant Cys559Gly inPostepy psychiatrii neurologii · 2026
    Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sherihan Rezk AhmedDepartment of Neurology, Faculty of Medicine, Kafr el-Sheikh University, 12 Elgeish street, Kafr el-sheikh, 33511, Egypt. sherihanrezk2016@gmail.com.ORCID http://orcid.org/0000-0001-7129-1819
Amr Abdel Monem MohamedDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Haitham Hamdy SalemDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Shahinaz HelmyDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ramez Reda MoustafaDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. ramezm@msn.com.
Sherien Mohamed Farag BorhamDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ain Shams University · EGKafrelsheikh University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhite matter hyperintensities (WMHs) are frequently found in migraineurs. However, their clinical significance and correlation to different migraine phenotypes and treatment responses are not well defined. The study aimed to examine the association of WMHs with migraine clinical patterns and treatment response. AIM OF WORK: We aimed to evaluate the association between WMHs and migraine phenotypes and explore the relationship of WMHs to treatment response.

methodsOur cross-sectional study formed of 500 migraineurs who sought treatment in Kafr el-sheik university hospital and underwent (3 T) MRI to evaluate WMHs. Different migraine phenotypes were compared between patients with and without WMHs. According to reduced headache pain intensity and frequency, these patients were divided into treatment responder and non-responder groups.

resultsA total of 145 patients (29%) had WMHs. Patients with WMHs were significantly older, had a longer disease duration, and higher attack frequency. Patients who did not respond to acute and maintenance medications had a higher frequency of WMHs and high WMHs Scheltens score. Migraine with Aura and the presence of vomiting and dizziness were predictors for the development of WMHs.

conclusionWMHs are more common in migraine with aura. It is more frequent in migraine associated with vomiting and dizziness. WMHs increased with advancing age and more severe disease burden. Poorer response to acute and prophylactic medications was found in patients with WMHs.

Indexed as

EpilepsyLeukoaraiosisMigraine DisordersMigraine with AuraWhite MatterCross-Sectional StudiesDizzinessHumansMagnetic Resonance ImagingVertigoMigraine phenotypesMigraine treatment responseWMHs

Identifiers

PMID35854172
PMCPMC10505107
OpenAlexW4285795577

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.