Evidence map›Paper›PMID 35853943›Full record

ArticleSchizophrenia (Heidelberg, Germany)2022

Automatic language analysis identifies and predicts schizophrenia in first-episode of psychosis.

Alicia Figueroa-Barra, Daniel Del Aguila, Mauricio Cerda, Pablo A Gaspar, Lucas D Terissi, Manuel Durán, Camila Valderrama

Abstract read
In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. A single composite index of semantic behavior tracks symptoms of psychosis over time.medRxiv : the preprint server for health sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alicia Figueroa-BarraDepartment of Psychiatry, Faculty of Medicine, Universidad de Chile, Santiago, Chile. aliciafigueroa@uchile.cl.
Daniel Del AguilaArtificial Intelligence Development Department, BiosIntelligence, GrupoBios, Santiago, Chile.
Mauricio CerdaBiomedical Neuroscience Institute, Santiago, Chile.
Pablo A GasparDepartment of Psychiatry, Faculty of Medicine, Universidad de Chile, Santiago, Chile.ORCID http://orcid.org/0000-0002-9682-5327
Lucas D TerissiLaboratory for System Dynamics & Signal Processing, Universidad Nacional de Rosario and CIFASIS, Santa Fe, Argentina.
Manuel DuránIntegrative Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Camila ValderramaIntegrative Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

Funding

Ministry of Education, Government of Chile | National Commission for Scientific and Technological Research | Fondo de Fomento al Desarrollo Científico y Tecnológico (FONDEF) ID20I10371
6 · The paper itself

Abstract

Automated language analysis of speech has been shown to distinguish healthy control (HC) vs chronic schizophrenia (SZ) groups, yet the predictive power on first-episode psychosis patients (FEP) and the generalization to non-English speakers remain unclear. We performed a cross-sectional and longitudinal (18 months) automated language analysis in 133 Spanish-speaking subjects from three groups: healthy control or HC (n = 49), FEP (n = 40), and chronic SZ (n = 44). Interviews were manually transcribed, and the analysis included 30 language features (4 verbal fluency; 20 verbal productivity; 6 semantic coherence). Our cross-sectional analysis showed that using the top ten ranked and decorrelated language features, an automated HC vs SZ classification achieved 85.9% accuracy. In our longitudinal analysis, 28 FEP patients were diagnosed with SZ at the end of the study. Here, combining demographics, PANSS, and language information, the prediction accuracy reached 77.5% mainly driven by semantic coherence information. Overall, we showed that language features from Spanish-speaking clinical interviews can distinguish HC vs chronic SZ, and predict SZ diagnosis in FEP patients.

Identifiers

PMID35853943
PMCPMC9261086

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.