ArticleNature communications2022
[
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026Review
- Gut microbiota as a modulator of HDAC: insights into Alzheimer's disease treatment.Pharmacological reports : PR · 2026Review
- Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson's disease.Clinical epigenetics · 2026Article
- Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease?Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Intepirdine Derivatives Possessing Dual 5HT6 Antagonism / HDAC6 Inhibitory Activity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Histone Deacetylases in Neurodegenerative Diseases and Their Potential Role as Therapeutic Targets: Shedding Light on Astrocytes.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Review
- Martinostat as a novel HDAC inhibitor to overcome tyrosine kinase inhibitor resistance in chronic myeloid leukemia.Clinical epigenetics · 2025Article
- Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder.Annals of clinical and translational neurology · 2025Article
- Histone Deacetylation in Alzheimer's Diseases (AD); Hope or Hype.Cell biochemistry and biophysics · 2025Review
- The impact of sex on memory during aging and Alzheimer's disease progression: Epigenetic mechanisms.Journal of Alzheimer's disease : JAD · 2024Review
- Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study.iScience · 2024Article
- Epigenetics of Fear, Anxiety and Stress - Focus on Histone Modifications.Current neuropharmacology · 2024Article
- Aging imaging: the future demand of health management.European journal of nuclear medicine and molecular imaging · 2023Article
- Article
- The use of neuroimaging techniques in the early and differential diagnosis of dementia.Molecular psychiatry · 2023Review
- Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease.Aging cell · 2023Article
- Advances in PET/CT Imaging for Breast Cancer.Journal of clinical medicine · 2023Review
- Transcriptome analysis identifies the role of Class I histone deacetylase in Alzheimer's disease.Heliyon · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
37 authors at 4 institutions in 3 countries.
Tharick A PascoalTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-9057-8014
Mira ChamounTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Elad LaxDepartment of Molecular Biology, Ariel University, Ariel, Israel.ORCID http://orcid.org/0000-0002-0310-0520
Hsiao-Ying WeyDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Monica ShinTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Kok Pin NgTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Min Su KangTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-0745-6222
Sulantha MathotaarachchiTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Andrea L BenedetTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Joseph TherriaultTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-7826-4781
Firoza Z LussierTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-6877-4825
Frederick A SchroederNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Jonathan M DuBoisNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Baileigh G HightowerNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Tonya M GilbertNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Nicole R ZürcherNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Changning WangNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Robert HopewellMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Mallar ChakravartyDepartments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging Centre, Montreal, QC, Canada.
Melissa SavardTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Emilie ThomasTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Sara MohaddesTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Sarah FarzinDepartments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging Centre, Montreal, QC, Canada.
Alyssa SalaciakDepartments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging Centre, Montreal, QC, Canada.
Stephanie TulloDepartments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging Centre, Montreal, QC, Canada.
A Claudio CuelloDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-2143-2745
Jean-Paul SoucyMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Gassan MassarwehMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Heungsun HwangDepartment of Psychology, McGill University, Montreal, QC, Canada.
Eliane KobayashiMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Bradley T HymanDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Bradford C DickersonNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Marie-Christine GuiotMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Moshe SzyfDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Serge GauthierTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Jacob M HookerNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada. pedro.rosa@mcgill.ca.ORCID http://orcid.org/0000-0001-9116-1376
McGill University · CAHarvard University · USMontreal Neurological Institute and Hospital · CADouglas Mental Health University Institute · CA
Funding
Longitudinal multicenter head-to-head harmonization of tau PET tracersR01AG073267 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAKER, SUZANNE L, PASCOAL, THARICK · 2021 to 2025
$41.1MResearch Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5MProject 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8MImaging tau, amyloid, and neurodegeneration in PPAR01DC014296 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, JOHNSON, KEITH A. · 2016 to 2020
$4.3MHead-to-head comparisons of high-performance plasma phospho-tau epitopes for the detection of Alzheimer's diseaseR01AG075336 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tharick Pascoal · 2022 to 2026
$3.7MDesign of Class-specific HDAC Imaging Probes for Positron Emission TomographyR01DA030321 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI HOOKER, JACOB M. · 2010 to 2014
$2.4MCombined MRI/PET Imager for Simultaneous Acquisition of PET/MRI DataS10RR022976 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE · 2007 to 2007
$2.0MA Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0MCYCLOTRON &RADIOCHEMISTRY: SUBSTANCE ABUSE, COCAINE, OPIOIDS10RR017208 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2004
$500kPET CAMERA FOR BRAIN IMAGING: SCHIZOPHRENIA, BIPOLAR DISORDERS10RR019933 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$500kEpigenetic Mechanisms in human memory quantified by non-invasive PET imagingR21AG051931 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HOOKER, JACOB M. · 2016 to 2017
$470kTau Imaging in Atypical ADR21AG051987 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, MCGINNIS, SCOTT MICHAEL · 2016 to 2017
$470kCIHR FRN 152985CIHR MOP-11-51-31NCRR NIH HHS S10 RR017208NCRR NIH HHS S10 RR019933NCRR NIH HHS S10 RR022976NCRR NIH HHS S10 RR023401NCRR NIH HHS S10 RR026666NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG073267NIA NIH HHS R01 AG075336NIA NIH HHS R21 AG051931NIA NIH HHS R21 AG051987NIBIB NIH HHS P41 EB015896NIDA NIH HHS R01 DA030321NIDCD NIH HHS R01 DC014296
Abstract
Alzheimer's disease (AD) is characterized by the brain accumulation of amyloid-β and tau proteins. A growing body of literature suggests that epigenetic dysregulations play a role in the interplay of hallmark proteinopathies with neurodegeneration and cognitive impairment. Here, we aim to characterize an epigenetic dysregulation associated with the brain deposition of amyloid-β and tau proteins. Using positron emission tomography (PET) tracers selective for amyloid-β, tau, and class I histone deacetylase (HDAC I isoforms 1-3), we find that HDAC I levels are reduced in patients with AD. HDAC I PET reduction is associated with elevated amyloid-β PET and tau PET concentrations. Notably, HDAC I reduction mediates the deleterious effects of amyloid-β and tau on brain atrophy and cognitive impairment. HDAC I PET reduction is associated with 2-year longitudinal neurodegeneration and cognitive decline. We also find HDAC I reduction in the postmortem brain tissue of patients with AD and in a transgenic rat model expressing human amyloid-β plus tau pathology in the same brain regions identified in vivo using PET. These observations highlight HDAC I reduction as an element associated with AD pathophysiology.
Indexed as
Alzheimer DiseaseCognitive DysfunctionHistone Deacetylase 1AdamantaneAmyloid beta-PeptidesAnimalsBrainHistone DeacetylasesHumansHydroxamic AcidsPositron-Emission TomographyRatstau ProteinsAdamantaneAmyloid beta-PeptidesHDAC1 protein, humanHdac1 protein, ratHistone Deacetylase 1Histone DeacetylasesHydroxamic Acidsmartinostattau Proteins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.