ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Structural Covariance and Heritability of the Optic Tract and Primary Visual Cortex in Living Human Brains.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Unpacking the V1 map: Differential covariation of preferred spatial frequency and cortical magnification across spatial dimensions.PLoS computational biology · 2025Article
- Evaluating the impact of denoising diffusion MRI data on tractometry metrics of optic tract abnormalities in glaucoma.Scientific reports · 2025Article
- Tractometry of Human Visual White Matter Pathways in Health and Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- Comparing retinotopic maps of children and adults reveals a late-stage change in how V1 samples the visual field.Nature communications · 2023Article
- Retinal ganglion cell endowment is correlated with optic tract fiber cross section, not density.NeuroImage · 2022Article
- Linking individual differences in human primary visual cortex to contrast sensitivity around the visual field.Nature communications · 2022Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Individual differences among human brains exist at many scales, spanning gene expression, white matter tissue properties, and the size and shape of cortical areas. One notable example is an approximately 3-fold range in the size of human primary visual cortex (V1), a much larger range than is found in overall brain size. A previous study (Andrews et al., 1997) reported a correlation between optic tract (OT) cross-section area and V1 size in postmortem human brains, suggesting that there may be a common developmental mechanism for multiple components of the visual pathways. We evaluated the relationship between properties of the OT and V1 in a much larger sample of living human brains by analyzing the Human Connectome Project (HCP) 7 Tesla Retinotopy Dataset (including 107 females and 71 males). This dataset includes retinotopic maps measured with functional MRI (fMRI) and fiber tract data measured with diffusion MRI (dMRI). We found a negative correlation between OT fractional anisotropy (FA) and V1 surface area (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.