Evidence map›Paper›PMID 35853589›Full record

ArticleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2023

Duration of infectious shedding of SARS-CoV-2 Omicron variant and its relation with symptoms.

Şiran Keske, Gülen Güney-Esken, Cansel Vatansever, Yeşim Beşli, Zeynep Ece Kuloğlu, Zeliş Nergiz, Tayfun Barlas, Özgür Şencanlı, Mert Ahmet Kuşkucu, Erhan Palaoğlu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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  11. Timing and Predictors of Loss of Infectivity Among Healthcare Workers With Mild Primary and Recurrent COVID-19: A Prospective Observational Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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  20. Omicron variant: assessing the duration of viral shedding and its implications.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Şiran KeskeDepartment of Infectious Diseases and Clinical Microbiology, Koç University School of Medicine, Istanbul, Turkey; Koç University-Isbank Center for Infectious Diseases, Turkey. Electronic address: sirankeske@yahoo.com.
Gülen Güney-EskenKoç University-Isbank Center for Infectious Diseases, Turkey.
Cansel VatanseverKoç University-Isbank Center for Infectious Diseases, Turkey; Department of Clinical Microbiology, Koç University School of Medicine, Istanbul, Turkey.
Yeşim BeşliDepartment of Medical Microbiology, VKV American Hospital, Istanbul, Turkey.
Zeynep Ece KuloğluKoç University-Isbank Center for Infectious Diseases, Turkey; Department of Clinical Microbiology, Koç University School of Medicine, Istanbul, Turkey.
Zeliş NergizKoç University-Isbank Center for Infectious Diseases, Turkey; Department of Clinical Microbiology, Koç University School of Medicine, Istanbul, Turkey.
Tayfun BarlasKoç University-Isbank Center for Infectious Diseases, Turkey.
Özgür ŞencanlıDepartment of Occupational Medicine, VKV American Hospital, Istanbul, Turkey.
Mert Ahmet KuşkucuKoç University-Isbank Center for Infectious Diseases, Turkey.
Erhan PalaoğluDepartment of Medical Microbiology, VKV American Hospital, Istanbul, Turkey.
Füsun CanKoç University-Isbank Center for Infectious Diseases, Turkey; Department of Clinical Microbiology, Koç University School of Medicine, Istanbul, Turkey.
Önder ErgönülDepartment of Infectious Diseases and Clinical Microbiology, Koç University School of Medicine, Istanbul, Turkey; Koç University-Isbank Center for Infectious Diseases, Turkey. Electronic address: oergonul@ku.edu.tr.
Koç University · TRAmerikan Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSARS-CoV-2 infections with Omicron variants have a high capability of human-to-human transmission. Nevertheless, the duration of isolation for mild cases was shortened to 5 to 7 days. We aimed to detect the duration of viral shedding among healthcare workers (HCWs) with Omicron by using viral culture.

methodsWe prospectively included newly diagnosed nonsevere, symptomatic SARS-CoV-2 positive HCWs. Nasopharyngeal swab samples were obtained consecutively on days 5, 7,10, and 14 of onset of symptoms. The samples were examined by nucleic acid amplification test and viral culture.

resultsIn total, 55 non-severe patients with SARS-CoV-2 Omicron variant were included. The mean age of the population was 34 years (range, 23 to 54) and 78% (43/55) were female. The PCR positivity rate on days 5, 7, 10, and 14 was 96.4% (53/55), 87.3% (48/55), 74.545% (41/55), and 41.8% (23/55) consecutively, whereas the viral culture positivity rates were 83% (44/53), 52% (26/50), 13.5% (7/52), and 8% (4/50). Among the patients who became symptom-free, the viral culture positivity rates were 100% (4/4), 58% (7/12), 11% (3/27), and 5% (2/41). DISCUSSION: We showed that among the SARS-CoV-2 Omicron variant infected patients, viral shedding continues for ≥10 days in 13.5% of all cases and 11% in symptom-free cases. The decision for cessation of isolation according to the presence of symptoms could be reconsidered until further studies disapprove of our results. Meanwhile, the infected HCWs who give care to high-risk patients for severe COVID-19 might extend their isolations ≤10 days after the onset of symptoms, regardless of their symptoms.

Indexed as

Communicable DiseasesCOVID-19AdultCOVID-19 TestingFemaleHumansMaleMiddle AgedSARS-CoV-2Virus SheddingYoung AdultCOVID-19PCRSARS CoV-2SheddingViral culture

Identifiers

PMID35853589
PMCPMC9287585
OpenAlexW4285601001

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.