Evidence map›Paper›PMID 35853476›Full record

ArticleNature2022

Archaic chaperone-usher pili self-secrete into superelastic zigzag springs.

Natalia Pakharukova, Henri Malmi, Minna Tuittila, Tobias Dahlberg, Debnath Ghosal, Yi-Wei Chang, Si Lhyam Myint, Sari Paavilainen, Stefan David Knight, Urpo Lamminmäki and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. A Novel Pilus System in Candidate Phyla Radiation Bacteria.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Tat-dependent bundling pilus of a halophilic archaeon assembles by a strand donation mechanism and facilitates biofilm formation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Natalia Pakharukova *Joint Biotechnology Laboratory, MediCity, Faculty of Medicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-8363-6105
Henri Malmi *Joint Biotechnology Laboratory, MediCity, Faculty of Medicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0001-9872-8523
Minna TuittilaJoint Biotechnology Laboratory, MediCity, Faculty of Medicine, University of Turku, Turku, Finland.
Tobias DahlbergDepartment of Physics, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
Debnath GhosalDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Yi-Wei ChangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-2391-473X
Si Lhyam MyintDepartment of Molecular Biology, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
Sari PaavilainenJoint Biotechnology Laboratory, MediCity, Faculty of Medicine, University of Turku, Turku, Finland.
Stefan David KnightDepartment of Cell and Molecular Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-7180-8758
Urpo LamminmäkiDepartment of Life Technologies, University of Turku, Turku, Finland.
Bernt Eric UhlinDepartment of Molecular Biology, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-2991-8072
Magnus AnderssonDepartment of Physics, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-9835-3263
Grant JensenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-1556-4864
Anton V ZavialovJoint Biotechnology Laboratory, MediCity, Faculty of Medicine, University of Turku, Turku, Finland. anton.zavialov@utu.fi.ORCID http://orcid.org/0000-0001-6191-5931
University of Turku · FIUmeå University · SECalifornia Institute of Technology · USUppsala University · SE

Funding

Structure and Function of Pathogenesis-Associated Bacterial Structures by Electron CryotomographyR01AI127401 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRANT J JENSEN · 2016 to 2026
$3.9M
NIAID NIH HHS R01 AI127401
6 · The paper itself

Abstract

Adhesive pili assembled through the chaperone-usher pathway are hair-like appendages that mediate host tissue colonization and biofilm formation of Gram-negative bacteria

Indexed as

Acinetobacter baumanniiCryoelectron MicroscopyFimbriae, BacterialMolecular ChaperonesElasticityFimbriae ProteinsFimbriae ProteinsMolecular Chaperones

Identifiers

PMID35853476
PMCPMC9452303
OpenAlexW4286218312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.