Evidence map›Paper›PMID 35852692›Full record

ArticleBulletin of experimental biology and medicine2022

A New Berberine Preparation Protects Pancreatic Islet Cells from Apoptosis Mediated by Inhibition of Phospholipase A

X J Bi, Y Q Lv, X H Yang, Y Ge, H Han, J S Feng, M Zhang, L Chen, M Z Xu, F Y Guan

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

X J BiDepartment of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, China.
Y Q LvDepartment of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, China.
X H YangDepartment of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, China.
Y GeDepartment of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, China.
H HanDepartment of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, China.
J S FengDepartment of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, China.
M ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, China.
L ChenDepartment of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, China.
M Z XuDepartment of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, China. ms002@jlu.edu.cn.
F Y GuanDepartment of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, China. guanfy@jlu.edu.cn.
Jilin Medical University · CNJilin University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied an amorphous solid dispersion of berberine with absorption enhancer sodium caprate (Huang-Gui solid dispersion preparations, HGSD). A therapeutic effect of HGSD was revealed in mice with type 2 diabetes mellitus and palmitate-induced injury to MIN6 β-cells. HGSD treatment (150 mg/kg) improved glucose metabolism and decreased β-cell apoptosis in diabetic mice. Furthermore, the effective component of HGSD berberine significantly attenuated the palmitate-induced decrease in MIN6 β-cells viability and insulin secretion. Moreover, molecular docking analysis and Western blotting showed that berberine decreased cell apoptosis and expression of group VIA phospholipase A

Indexed as

BerberineDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Insulin-Secreting CellsIslets of LangerhansAnimalsApoptosisMiceMolecular Docking Simulationp38 Mitogen-Activated Protein KinasesPalmitatesPhospholipasesPhospholipases A2, Calcium-IndependentBerberinep38 Mitogen-Activated Protein KinasesPalmitatesPhospholipasesPhospholipases A2, Calcium-Independentapoptosisberberinediabetesgroup VIA phospholipase A2 (iPLA2)islet cells

Identifiers

PMID35852692
OpenAlexW4285795869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.