Evidence map›Paper›PMID 35852689›Full record

ArticleBulletin of experimental biology and medicine2022

Antimicrobial Activity of the Serum before and after Vaccination with EpiVacCorona.

V G Arzumanyan, E P Bystritskaya, T I Kolyganova, A M Iksanova, P V Samoilikov, S Yu Konanykhina, A A Vartanova, O A Svitich

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

V G ArzumanyanI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia. veraar@mail.ru.
E P BystritskayaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
T I KolyganovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
A M IksanovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
P V SamoilikovI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
S Yu KonanykhinaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
A A VartanovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
O A SvitichI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the effect of vaccination with anti-COVID-19 vaccine EpiVacCorona on serum antimicrobial activity, formation of specific IgG antibodies, and expression of some antimicrobial peptides. Antimicrobial activity of the serum from 55 volunteers towards S. aureus cells was measured spectrophotometrically; IgG-antibodies against SARS-CoV-2 antigen were assayed by ELISA; expression of genes encoding antimicrobial peptides LL37, HBD1, and HBD2 was evaluated by PCR with reverse transcription. Total antimicrobial serum activity and activity of its low-molecular-weight fraction containing antimicrobial peptides demonstrated an inverse correlation. Both activities after vaccination increased in case of low initial values, but decreased in case of high initial values. The vector of change of specific IgG antibodies to coronavirus inversely correlated with the vector of change of activity of antimicrobial peptide fraction. The expression of genes of antimicrobial peptides LL37, HBD1, and HBD2 looked like normal distribution depending on activities of the antimicrobial peptides in the corresponding sera.

Indexed as

Anti-Infective Agentsbeta-DefensinsCOVID-19Antibodies, ViralCOVID-19 VaccinesHumansImmunoglobulin GSARS-CoV-2Staphylococcus aureusVaccinationVaccines, SyntheticAntibodies, ViralAnti-Infective Agentsbeta-DefensinsCOVID-19 VaccinesEpiVacCorona vaccineImmunoglobulin GVaccines, Syntheticantimicrobial activityantimicrobial peptidesEpiVacCoronaserumvaccination

Identifiers

PMID35852689
PMCPMC9294802
OpenAlexW4285794626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.