ReviewMedical oncology (Northwood, London, England)2022
The role of PIP5K1A in cancer development and progression.
Review in Medical oncology (Northwood, London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Brief report: Therapeutic benefit of ISA-2011B in colorectal cancer.Molecular biology reports · 2026Article
- GPR176 enhances the epithelial‑mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway.Oncology reports · 2026Article
- Article
- Implicates of PIP5K1α in asthma-related biological processes: insights into mechanisms and therapeutic potential.Journal of translational medicine · 2025Review
- PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Migrasomes: key players in immune regulation and promising medical applications.Frontiers in immunology · 2025Review
- Truncated O-glycosylation in metastatic triple-negative breast cancer reveals a gene expression signature associated with extracellular matrix and proteolysis.Scientific reports · 2024Article
- Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.Nutrients · 2023Article
- The Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets.Brain sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Malignant tumors are formed via a pathological process of uncontrolled cell division that seriously endangers human physical and mental health. The PI3K/AKT signaling pathway plays an important role in the occurrence and development of various cancers. As a lipid kinase, PIP5K1A acts on the upstream of the PI3K/AKT signaling pathway and has a variety of biological functions, including cell differentiation, cell migration, and sperm development. An increasing number of studies have shown that the overexpression of PIP5K1A promotes the growth, invasion, and migration of cancer cells, and the inhibition of PIP5K1A can effectively hinder tumor progression. These findings imply that PIP5K1A are potential markers and targets for cancers. The aim of this study was to systemically review the structure and function of PIP5K1A, the relationship between PIP5K1A and tumors and the potential therapeutic value of PIP5K1A inhibitors in cancer. PIP5K1A affects the occurrence and progression of many tumors and will provide new strategies for cancer diagnosis and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.