Evidence map›Paper›PMID 35852551›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2022

Resolvin D5 disrupts anxious- and depressive-like behaviors in a type 1 diabetes mellitus animal model.

Felipe Fagundes Leão, Ana Paula Farias Waltrick, Waldiceu Aparecido Verri, Joice Maria da Cunha, Janaina Menezes Zanoveli

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Felipe Fagundes LeãoLaboratory of Neuropsychopharmacology, Department of Pharmacology, Biological Sciences Building, Federal University of Paraná, Rua Coronel H. Dos Santos S/N, P.O. Box 19031, Curitiba, Paraná, ZIP Code 81540-990, Brazil.
Ana Paula Farias WaltrickLaboratory of Neuropsychopharmacology, Department of Pharmacology, Biological Sciences Building, Federal University of Paraná, Rua Coronel H. Dos Santos S/N, P.O. Box 19031, Curitiba, Paraná, ZIP Code 81540-990, Brazil.
Waldiceu Aparecido VerriLaboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Rod. Celso Garcia Cid Km 480 PR445, P.O. Box 10.011, Londrina, Paraná, ZIPCode86057-970, Brazil.
Joice Maria da CunhaLaboratory of Neuropsychopharmacology, Department of Pharmacology, Biological Sciences Building, Federal University of Paraná, Rua Coronel H. Dos Santos S/N, P.O. Box 19031, Curitiba, Paraná, ZIP Code 81540-990, Brazil.
Janaina Menezes ZanoveliLaboratory of Neuropsychopharmacology, Department of Pharmacology, Biological Sciences Building, Federal University of Paraná, Rua Coronel H. Dos Santos S/N, P.O. Box 19031, Curitiba, Paraná, ZIP Code 81540-990, Brazil. janaina.zanoveli@ufpr.br.
Universidade Federal do Paraná · BRUniversidade Estadual de Londrina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes mellitus (T1DM) is a chronic disease related to a persistent inflammatory process reaching the central nervous system, which leads to psychiatric comorbidities such as depression and anxiety. The search for new therapeutic agents effective in alleviating the psychiatric condition associated with T1DM becomes critical. Using an animal model of T1DM, we aimed to evaluate the effect of a specific specialized pro-resolving lipid mediator Resolvin D5 (RvD5), in preventing behaviors related to depression and anxiety, investigating its influence on inflammasome in interleukin (IL)-1β in the hippocampus and prefrontal cortex. After experimental T1DM induction with streptozotocin (60 mg/kg, i.p.), these animals were treated for 23 days and randomly divided into 6 subgroups according to the treatment: vehicle (VEH), the antidepressant Fluoxetine (FLX; 10 mg/kg), the nonsteroidal anti-inflammatory Ibuprofen (IBU; 30 mg/kg) or Resolvin D5 (RvD5; 1 3, or 10 ng/animal). As a control group for the experimental-T1DM condition, a group of normoglycemic animals treated with VEH underwent the same behavioral tests: elevated plus maze, open field, and modified forced swimming tests. In the end, hippocampus and prefrontal cortex samples were processed to analyze the pro-inflammatory cytokine IL-1β levels. Our data showed that RvD5 treatment prevented the more pronounced anxious-like and reduced the depressive-like behaviors of experimental-T1DM animals and significantly improved the plasma glucose levels. Additionally, RvD5 treatment prevented the increased level of pro-inflammatory cytokine IL-1β in the hippocampus and prefrontal cortex of experimental-T1DM rats. To conclude, RvD5 presents a preventive therapeutic potential in impairing the development of the emotional complications resulting from T1DM. This potential may be related to its protective profile, as demonstrated in this study by its pro-resolutive action on neuroinflammation in the hippocampus and prefrontal cortex.

Indexed as

Diabetes Mellitus, Type 1AnimalsAnxietyBehavior, AnimalCytokinesDepressionDisease Models, AnimalDocosahexaenoic AcidsHippocampusRatsCytokinesDocosahexaenoic Acidsresolvin D5Anxiety, DepressionElevated plus mazeForced swimming testSpecialized pro-resolving lipid mediatorsStreptozotocin

Identifiers

PMID35852551
OpenAlexW4285799450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.