Trial reportTranslational behavioral medicine2022
Meaning-Centered Psychotherapy for Cancer Caregivers: A pilot trial among caregivers of patients with glioblastoma multiforme.
Trial report in Translational behavioral medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Efficacy of an Online Meaning-Centered Psychotherapy in Caregivers of Advanced Cancer (eMCP-C): A Mixed-Method Pilot Randomized Controlled Trial.Psycho-oncology · 2026Trial
- A randomized controlled trial of a distress screening, consultation, and targeted referral system for family caregivers in oncologic care.Psycho-oncology · 2024Trial
- Meaning-centered psychotherapy for Chinese caregivers of patients with advanced cancer: Cultural and linguistic adaptation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Meaning-Centered Psychotherapy for Psilocybin-Assisted Therapy Among Patients with Advanced Cancer and Depression: Rationale and Preliminary Evaluation of MCP-PSIL.Psychedelic medicine (New Rochelle, N.Y.) · 2026Article
- Meaning-Centered Psychotherapy for Cancer Caregivers: Study protocol of a randomized controlled trial.Trials · 2026Article
- It's all about the relationship: The caregiver experience of supporting a person with advanced cancer going through an LSD microdosing trial.Palliative & supportive care · 2026Article
- Meaning-Centered Psychotherapy for Cancer Caregivers Study protocol of a randomized controlled trial.Research square · 2026Article
- Canadian Expert Consensus Recommendations for the Diagnosis and Management of Glioblastoma: Results of a Delphi Study.Current oncology (Toronto, Ont.) · 2025Article
- Former Primary Caregivers of Patients With Glioblastoma Multiforme Evaluate the PATH (Preparedness Assessment for the Transition Home) Instrument.Journal of advanced nursing · 2025Article
- Reporting standards in randomized controlled trials involving neuro-oncology caregivers: A systematic review report from the RANO-Cares working group.Neuro-oncology practice · 2025Article
- Adaptation of meaning-centered psychotherapy for healthcare providers to buffer work-induced distress and improve wellbeing.Translational behavioral medicine · 2025Article
- The adaptation of meaning centered psychotherapy to develop RELOAD-C: a web-based tool to reduce loneliness in caregivers of persons with Alzheimer's disease and related dementias.Translational behavioral medicine · 2025Article
- The impact of a primary brain tumor diagnosis on caregivers: Insights from the patients' perspective.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- The Power of a Belief System: A Systematic Qualitative Synthesis of Spiritual Care for Patients with Brain Tumors.Journal of clinical medicine · 2024Review
- Benefit finding among family caregivers of patients with advanced cancer in a palliative treatment: a qualitative study.BMC nursing · 2024Article
- Existential distress in family caregivers: scoping review of meaning-making interventions.BMJ supportive & palliative care · 2024Article
- Acceptance of Caregiver-Patient Support to Latinx Coping with Advanced Cancer (CASA) Intervention: A Caregiver Case Study.International journal of environmental research and public health · 2023Article
- Self-Reported Well-Being of Family Caregivers of Children with Medical Complexity.Academic pediatricsArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Caregivers of patients with glioblastoma multiforme (GBM) are at significant risk for existential distress. Such distress negatively impacts caregivers' quality of life and capacity to serve in their role as healthcare proxies, and ultimately, contributes to poor bereavement outcomes. Our team developed Meaning-Centered Psychotherapy for Cancer Caregivers (MCP-C), the first targeted psychosocial intervention that directly addresses existential distress in caregivers. The purpose of this study was to evaluate the feasibility, acceptability, and preliminary effects of MCP-C among caregivers of patients with GBM via a mixed-method pilot trial. Caregivers were randomized to seven sessions of MCP-C or Enhanced Usual Care (EUC), which included distress screening and the provision of targeted referrals and completed quantitative assessments at baseline (T1), after completion of MCP-C (T2), and at 2-month follow-up (T3). A subset of participants engaged in semistructured interviews at T2. Of 60 caregivers randomized, 55 were evaluable for preliminary efficacy analysis. Constrained linear mixed models indicated the MCP-C arm had statistically significant improvement relative to the EUC arm in the primary outcome of personal meaning and multiple secondary outcomes, including benefit finding, depressive symptomatology, and spiritual wellbeing. MCP-C demonstrated preliminary efficacy in facilitating caregivers' capacity to experience a sense of meaning and purpose despite the challenges and suffering associated with providing care to patients with GBM. Future studies are needed among more diverse samples of caregivers and should include the opportunity for concurrent patient enrollment to allow for a reciprocal and augmented experience of meaning among patient-caregiver dyads.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.