ArticleCancer medicine2023
Major depression disorder may causally associate with the increased breast cancer risk: Evidence from two-sample mendelian randomization analyses.
Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Investigating the relationship between depression and breast cancer: observational and genetic analyses.BMC medicine · 2023Pooled it
- Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study.Npj mental health research · 2026Article
- Psychosomatics at the threshold: cancer, mood disorders, and the mental pain of death - where precision medicine meets spirituality.Frontiers in psychiatry · 2026Article
- Depression, antidepressant use, and breast cancer incidence: results from the E3N prospective cohort.Psychiatry and clinical neurosciences · 2025Article
- Independent effects of mental health disorders on breast cancer and their mediating factors: evidence from NHANES and two-step Mendelian randomization.Discover oncology · 2025Article
- Deciphering the Overlapping Immune Mechanism Between Depression and Breast Cancer.International journal of molecular sciences · 2025Article
- A Causal Effect of Serum 25(OH)D Level on Appendicular Muscle Mass: Evidence From NHANES Data and Mendelian Randomization Analyses.Journal of cachexia, sarcopenia and muscle · 2025Article
- Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case-control study.European archives of psychiatry and clinical neuroscience · 2025Article
- Causal Relationship Between Different Sleep Traits and Dental Caries: A Bidirectional Mendelian Randomization Study.International journal of behavioral medicine · 2025Article
- Association between sleep duration, depression and breast cancer in the United States: a national health and nutrition examination survey analysis 2009-2018.Annals of medicine · 2024Article
- Exploring the Missing link between vitamin D and autism spectrum disorder: Scientific evidence and new perspectives.Heliyon · 2024Article
- Causality between six psychiatric disorders and digestive tract cancers risk: a two-sample Mendelian randomization study.Scientific reports · 2024Article
- Identification of shared gene signatures in major depressive disorder and triple-negative breast cancer.BMC psychiatry · 2024Article
- Article
- Trajectories of depressive symptoms and risk of cardiovascular disease, cancer and mortality: a prospective cohort study.General psychiatry · 2024Article
- Subjective and Personal Characteristics of Women with Breast Cancer: A Factorial Model of Disease Risks and the Course of Disease.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Cancer mortality in Common Mental Disorders: A 10-year retrospective cohort study.Social psychiatry and psychiatric epidemiology · 2023Article
- Major depression disorder may causally associate with the increased breast cancer risk: Evidence from two-sample mendelian randomization analyses.Cancer medicine · 2023Article
- Severe mental illness and the risk of breast cancer: A two-sample, two-step multivariable Mendelian randomization study.PloS one · 2023Article
- An exploration of the correlations between seven psychiatric disorders and the risks of breast cancer, breast benign tumors and breast inflammatory diseases: Mendelian randomization analyses.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMajor depression disorder (MDD) has been associated with increased breast cancer risk in epidemiological studies; however, it is still unknown whether this association is causal or not. The aim of this study is to determine the causal relationship between MDD and breast cancer risk.
methodsTwo-sample Mendelian randomization (MR) analyses with 92 single-nucleotide polymorphisms (SNPs) significantly associated with MDD as instrumental variables (IVs) were performed. Effects of these SNPs on breast cancer in women were estimated in the Breast Cancer Association Consortium (122,977 cases and 105,974 controls) using inverse variance weighted (IVW), weighted median and multivariable MR models. Heterogeneity and pleiotropy effects were assessed based on IVW and MR-Egger regression model, respectively.
resultsAn 8.7% increased risk of overall breast cancer [odds ratio (OR) = 1.087; 95% confidence interval (CI) 1.011-1.170; P = 0.025] per log-odds ratio increment of MDD risk based on the IVW model was noticed. Similar results were obtained with the multivariable MR model (OR = 1.118, 95% CI = 1.010-1.237; P = 0.031). An increment but not statistically significant causality association was noticed between MDD and risk of ER+ (OR = 1.098, 95% CI = 0.984-1.227; P = 0.093) or ER- (OR = 1.129, 95% CI = 0.982-1.297; P = 0.089) breast cancer under multivariable MR model. No significant pleiotropy effects were observed for the IVs in the two-sample MR studies.
conclusionsThe results suggested that a genetic predisposition of MDD is causally associated with overall breast cancer risk; however, the underlying biological mechanisms are worthy of further study.
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