Evidence map›Paper›PMID 35852146›Full record

ArticleeLife2022

Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth.

Michael Sean Mauro, Gunta Celma, Vitaly Zimyanin, Magdalena M Magaj, Kimberley H Gibson, Stefanie Redemann, Shirin Bahmanyar

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  9. Article
  10. Advances in the understanding of nuclear pore complexes in human diseases.Journal of cancer research and clinical oncology · 2024
    Review
  11. Nuclear transport proteins: structure, function, and disease relevance.Signal transduction and targeted therapy · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michael Sean MauroDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0001-7013-6139
Gunta CelmaDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.
Vitaly ZimyaninCenter for Membrane and Cell Physiology, University of Virginia, Charlottesville, United States.
Magdalena M MagajCenter for Membrane and Cell Physiology, University of Virginia, Charlottesville, United States.
Kimberley H GibsonCenter for Cellular and Molecular Imaging: Electron Microscopy, Department of Cell Biology, Yale School of Medicine, New Haven, United States.ORCID 0000-0001-8881-1411
Stefanie RedemannCenter for Membrane and Cell Physiology, University of Virginia, Charlottesville, United States.ORCID 0000-0003-2334-7309
Shirin BahmanyarDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0002-6583-5055
University of Virginia · USYale University · US

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
Defining the role of lipid metabolism in nuclear envelope identity and dynamicsR01GM131004 · NIGMS · YALE UNIVERSITY · PI Shirin Bahmanyar · 2019 to 2026
$2.8M
NIGMS NIH HHS R01 GM131004NIGMS NIH HHS T32 GM007223
6 · The paper itself

Abstract

The nuclear envelope (NE) assembles and grows from bilayer lipids produced at the endoplasmic reticulum (ER). How ER membrane incorporation coordinates with assembly of nuclear pore complexes (NPCs) to generate a functional NE is not well understood. Here, we use the stereotypical first division of the early

Indexed as

Nuclear PoreNuclear Pore Complex ProteinsAnimalsCaenorhabditis elegansCell NucleusNuclear EnvelopeNuclear Pore Complex ProteinsC. elegansC. elegans embryoscell biologylipid synthesisNDC1nuclear envelopenuclear pore complexNup107-160 complex

Identifiers

PMID35852146
PMCPMC9296133
OpenAlexW4285796352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.