Evidence map›Paper›PMID 35851978›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2022

Roles of natural resistance-associated macrophage protein-1 in modulating bacterial distribution and immune responses during Salmonella enterica serovar Typhimurium infection in murine pregnancy.

Gerard Agbayani, Kristina Clark, Subash Sad, Shawn P Murphy, Lakshmi Krishnan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Gerard AgbayaniDivision of Life Sciences, Human Health Therapeutics, National Research Council Canada, Ottawa, Ontario, Canada.
Kristina ClarkDivision of Life Sciences, Human Health Therapeutics, National Research Council Canada, Ottawa, Ontario, Canada.
Subash SadDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Shawn P MurphyDepartment of Obstetrics and Gynecology, University of Rochester, Rochester, New York, USA.
Lakshmi KrishnanDivision of Life Sciences, Human Health Therapeutics, National Research Council Canada, Ottawa, Ontario, Canada.ORCID 0000-0002-4122-6335
National Research Council Canada · CAUniversity of Ottawa · CAUniversity of Rochester · US

Funding

Mechanisms of placental infection by food-borne pathogensR01AI101049 · NIAID · UNIVERSITY OF ROCHESTER · PI KRISHNAN, LAKSHMI, MURPHY, SHAWN P · 2012 to 2016
$2.1M
NIAID NIH HHS R01 AI101049
6 · The paper itself

Abstract

problemSalmonella enterica serovar Typhimurium (S.Tm) infection in Nramp1 METHOD OF STUDY: Mice were systemically infected with S.Tm. Bacterial burden within spleen and individual placentas, and placental/fetal resorptions were quantified. Flow cytometric analysis of immune cell types in the spleen and individual placentas was performed. Cytokine expression in maternal serum was determined through cytometric bead array.

resultsSystemic infection with S.Tm resulted in preferential bacterial proliferation in placentas compared to the spleen in Nramp1

conclusionPregnancy compromises host resistance conferred by Nramp1 against S.Tm through compartment-specific regulation of maternal and placental cellular responses, and modulation of systemic cytokine expression.

Indexed as

Interleukin-10Salmonella InfectionsAnimalsCation Transport ProteinsCytokinesFemaleImmunityMiceNatural Resistance-associated Macrophage Protein 1PlacentaPregnancySalmonella typhimuriumSerogroupCation Transport ProteinsCytokinesInterleukin-10Natural Resistance-associated Macrophage Protein 1cytokinesinflammationNramp1placentapregnancySalmonella

Identifiers

PMID35851978
PMCPMC9509426
OpenAlexW4286229650

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.