ArticleNPJ digital medicine2022
Automated video-based assessment of facial bradykinesia in de-novo Parkinson's disease.
Article in NPJ digital medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Interaction- and asymmetry-aware facial blendshape analysis for objective quantification of Parkinsonian hypomimia.NPJ Parkinson's disease · 2026Article
- Artificial Intelligence and Digital Biomarkers for Early Detection and Monitoring of Neurological Disorders: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- NeuroSift for Task-Aware Quality Assurance of Multimedia Data in Remote Parkinson Disease Assessment: Machine Learning Model Development and Validation Study.Journal of medical Internet research · 2026Article
- From Prototype to Clinical Workflow: Co-Developing a Wearable Hypomimia System for Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Facial phenotypes in Alzheimer's disease: from neurobiology to artificial intelligence.Alzheimer's research & therapy · 2026Review
- Digital Technologies for Symptom Monitoring in Parkinson Disease.Current neurology and neuroscience reports · 2026Review
- Clinical and neuroimaging correlates of disease related gait patterns in patients with multiple system atrophy cerebellar type.Scientific reports · 2025Article
- Video-Based Data-Driven Models for Diagnosing Movement Disorders: Review and Future Directions.Movement disorders : official journal of the Movement Disorder Society · 2025Review
- Automatic analysis of eyelid movement in de-novo Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Dual stream transformer for medication state classification in Parkinson's disease patients using facial videos.NPJ digital medicine · 2025Article
- Explaining facial action units' correlation with hypomimia and clinical scores in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Is practitioner appraisal of facial expressivity and emotional engagement in simulated Parkinson's disease affected by race?Clinical parkinsonism & related disorders · 2025Article
- Using facial reaction analysis and machine learning to objectively assess the taste of medicines in children.PLOS digital health · 2024Article
- Unveiling early signs of Parkinson's disease via a longitudinal analysis of celebrity speech recordings.NPJ Parkinson's disease · 2024Article
- Rapid Voluntary Blinking as a Clinical Marker of Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Computerized analysis of hypomimia and hypokinetic dysarthria for improved diagnosis of Parkinson's disease.Heliyon · 2023Article
- Does Black vs. White race affect practitioners' appraisal of Parkinson's disease?NPJ Parkinson's disease · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Even though hypomimia is a hallmark of Parkinson's disease (PD), objective and easily interpretable tools to capture the disruption of spontaneous and deliberate facial movements are lacking. This study aimed to develop a fully automatic video-based hypomimia assessment tool and estimate the prevalence and characteristics of hypomimia in de-novo PD patients with relation to clinical and dopamine transporter imaging markers. For this cross-sectional study, video samples of spontaneous speech were collected from 91 de-novo, drug-naïve PD participants and 75 age and sex-matched healthy controls. Twelve facial markers covering areas of forehead, nose root, eyebrows, eyes, lateral canthal areas, cheeks, mouth, and jaw were used to quantitatively describe facial dynamics. All patients were evaluated using Movement Disorder Society-Unified PD Rating Scale and Dopamine Transporter Single-Photon Emission Computed Tomography. Newly developed automated facial analysis tool enabled high-accuracy discrimination between PD and controls with area under the curve of 0.87. The prevalence of hypomimia in de-novo PD cohort was 57%, mainly associated with dysfunction of mouth and jaw movements, and decreased variability in forehead and nose root wrinkles (p < 0.001). Strongest correlation was found between reduction of lower lip movements and nigro-putaminal dopaminergic loss (r = 0.32, p = 0.002) as well as limb bradykinesia/rigidity scores (r = -0.37 p < 0.001). Hypomimia represents a frequent, early marker of motor impairment in PD that can be robustly assessed via automatic video-based analysis. Our results support an association between striatal dopaminergic deficit and hypomimia in PD.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.