ArticleScientific reports2022
Sustained high body temperature exacerbates cognitive function and Alzheimer's disease-related pathologies.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Genetic and environmental risk factors for dementia in African adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Assessing racial disparities in dementia-related vulnerabilities: a machine learning analysis of social, environmental, and climate factors.Ethnicity & health · 2026Article
- Sexual dimorphism and photoperiodism in cognitive and neuronal ionic changes in scopolamine-induced cognitive impairment.Metabolic brain disease · 2026Article
- Flexible wearable medical devices: from material innovations and data processing to intelligent healthcare applications.Journal of advanced research · 2026Review
- Short-term effects and attributable burden of extreme heat and cold on dementia mortality: a case-time-series study in Hebei Province, China (2014-2022).BMC public health · 2026Article
- Neurobiophilia.Brain sciences · 2026Review
- Enzymatic Biomarkers for Early Diagnosis of Alzheimer's Disease: Uncovering Key Targets and Mechanisms.CNS & neurological disorders drug targets · 2026Review
- Fever Induces Long-Term Synaptic Enhancement and Protects Learning in an Accelerated Aging Model.Aging and disease · 2025Article
- Effects of ambient temperature on hospital admissions and mortality among older adults with and without dementia in South Korea.International journal of epidemiology · 2025Article
- Acute exercise impacts heart rate variability but not cognitive flexibility during subsequent simulated firefighter occupational tasks.European journal of applied physiology · 2025Article
- Phosphorylation-Induced Self-Coacervation versus RNA-Assisted Complex Coacervation of Tau Proteins.Journal of the American Chemical Society · 2025Article
- Dementia and Risks of Temperature-Related Mortality and Hospitalizations in Germany.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Cold-raising unmasks sleep disruption in amicroPublication biology · 2025Article
- Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions.International journal of nanomedicine · 2025Article
- Article
- Thermotherapy has Sexually Dimorphic Responses in APP/PS1 Mice.bioRxiv : the preprint server for biology · 2024Article
- Age-progressive interplay of HSP-proteostasis, ECM-cell junctions and biomechanics ensures C. elegans astroglial architecture.Nature communications · 2024Article
- Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer's Disease-Related Pathologies.International journal of molecular sciences · 2023Article
- Co-administration of Nanowired Oxiracetam and Neprilysin with Monoclonal Antibodies to Amyloid Beta Peptide and p-Tau Thwarted Exacerbation of Brain Pathology in Concussive Head Injury at Hot Environment.Advances in neurobiology · 2023Review
- Effects of Global Warming on Patients with Dementia, Motor Neuron or Parkinson's Diseases: A Comparison among Cortical and Subcortical Disorders.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Global warming is a serious public health threat to people worldwide. High body temperature is one of the important risk factors for Alzheimer's disease (AD), and the body temperature of AD patients has been found to be significantly higher than that of elderly control subjects. However, the effects of high body temperature on cognitive function and AD pathologies have not been completely elucidated. We report here that Tg2576 mice housed at a high ambient temperature of 30 °C for 13 months showed an increase in the body temperature, which is accompanied by memory impairment and an enhancement of amyloid-β peptides (Aβ) generation through the upregulation of β-site APP cleaving enzyme 1 (BACE1) level and decrease in the level of an Aβ-degrading enzyme, neprilysin (NEP) in the brain, compared with those of Tg2576 mice at 23 °C. High body temperature also increased the levels of heat shock proteins (HSPs), stress-stimulated kinases such as JNK, and total tau, leading to the enhancement of tau phosphorylation at 30 °C. Taken together, our findings suggest that high body temperature exacerbates cognitive function and AD pathologies, which provides a mechanistic insight for its prevention.
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