ArticleCerebral cortex (New York, N.Y. : 1991)2023
Selective corticofugal modulation on sound processing in auditory thalamus of awake marmosets.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Acoustic Flutter Processing in the Inferior Colliculus of Awake Marmosets: Complementary Rate Coding Modulated by Acoustic Parameters.Neuroscience bulletin · 2026Article
- FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems.iScience · 2025Article
- Subcortical origin of nonlinear sound encoding in auditory cortex.Current biology : CB · 2024Article
- Listening loops and the adapting auditory brain.Frontiers in neuroscience · 2023Article
- Lemniscal Corticothalamic Feedback in Auditory Scene Analysis.Frontiers in neuroscience · 2021Review
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Authors and funding
14 authors at 3 institutions in 1 country.
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Abstract
Cortical feedback has long been considered crucial for the modulation of sensory perception and recognition. However, previous studies have shown varying modulatory effects of the primary auditory cortex (A1) on the auditory response of subcortical neurons, which complicate interpretations regarding the function of A1 in sound perception and recognition. This has been further complicated by studies conducted under different brain states. In the current study, we used cryo-inactivation in A1 to examine the role of corticothalamic feedback on medial geniculate body (MGB) neurons in awake marmosets. The primary effects of A1 inactivation were a frequency-specific decrease in the auditory response of most MGB neurons coupled with an increased spontaneous firing rate, which together resulted in a decrease in the signal-to-noise ratio. In addition, we report for the first time that A1 robustly modulated the long-lasting sustained response of MGB neurons, which changed the frequency tuning after A1 inactivation, e.g. some neurons are sharper with corticofugal feedback and some get broader. Taken together, our results demonstrate that corticothalamic modulation in awake marmosets serves to enhance sensory processing in a manner similar to center-surround models proposed in visual and somatosensory systems, a finding which supports common principles of corticothalamic processing across sensory systems.
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