Evidence map›Paper›PMID 35851763›Full record

ArticlePhysiological reports2022

Activation of 2-oxoglutarate receptor 1 (OXGR1) by α-ketoglutarate (αKG) does not detectably stimulate Pendrin-mediated anion exchange in Xenopus oocytes.

John F Heneghan, Amar J Majmundar, Alicia Rivera, Jay G Wohlgemuth, Jeffrey S Dlott, L Michael Snyder, Friedhelm Hildebrandt, Seth L Alper

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

John F HeneghanDivision of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Amar J MajmundarDivision of Nephrology, Boston Children's Hospital, Boston, Massachusetts, USA.
Alicia RiveraDivision of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Jay G WohlgemuthQuest Diagnostics, Secaucus, New Jersey, USA.
Jeffrey S DlottQuest Diagnostics, Secaucus, New Jersey, USA.
L Michael SnyderQuest Diagnostics, Secaucus, New Jersey, USA.
Friedhelm HildebrandtDivision of Nephrology, Boston Children's Hospital, Boston, Massachusetts, USA.
Seth L AlperDivision of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6228-2512
Beth Israel Deaconess Medical Center · USQuest Diagnostics (United States) · USBoston Children's Hospital · US

Funding

The Child Heath Research CenterK12HD052896 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Wendy K Chung · 2007 to 2026
$7.9M
RESEARCH TRAINING IN PEDIATRIC NEPHROLOGYT32DK007726 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI BRISCOE, DAVID M. · 1994 to 2023
$5.9M
Delineation of pathogenic mechanisms of NOS1AP and TRIM8 mutations in monogenic SRNS/FSGS.K08DK125768 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI MAJMUNDAR, AMAR J · 2021 to 2025
$841k
Boston Children's HospitalNICHD NIH HHS K12 HD052896NIDDK NIH HHS K08 DK125768NIH HHS 1K08DK125768-01A1NIH HHS 5K12HD052896-13NIH HHS T32DK-007726
6 · The paper itself

Abstract

SLC26A4/Pendrin is the major electroneutral Cl

Indexed as

Ketoglutaric AcidsOocytesReceptors, Purinergic P2Sulfate TransportersAnimalsAnionsMiceXenopus laevisAnionsKetoglutaric AcidsReceptors, Purinergic P2Sulfate Transporterscortical collecting ductGPR99kidneytype B intercalated cell

Identifiers

PMID35851763
PMCPMC9294391
OpenAlexW4285810919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.