Evidence map›Paper›PMID 35851711›Full record

ArticleEuropean journal of heart failure2022

Prognostic significance of obstructive coronary artery disease in patients admitted with acute decompensated heart failure: the ARIC study community surveillance.

Zainali S Chunawala, Arman Qamar, Sameer Arora, Ambarish Pandey, Marat Fudim, Muthiah Vaduganathan, Robert J Mentz, Deepak L Bhatt, Melissa C Caughey

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Observational
  2. Article
  3. 2024 update in heart failure.ESC heart failure · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Zainali S ChunawalaDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX, USA.
Arman QamarSection of Interventional Cardiology and Vascular Medicine, Northshore University Healthsystem, Chicago, IL, USA.
Sameer AroraDivision of Cardiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Ambarish PandeyDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX, USA.
Marat FudimDivsion of Cardiology, Duke University School of Medicine, Duke Clinical Research Institute, Durham, NC, USA.
Muthiah VaduganathanDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Robert J MentzDivsion of Cardiology, Duke University School of Medicine, Duke Clinical Research Institute, Durham, NC, USA.
Deepak L BhattDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Melissa C CaugheyJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, USA.ORCID 0000-0001-8433-5147
Brigham and Women's Hospital · USDuke University · USThe University of Texas Southwestern Medical Center · USUniversity of North Carolina at Chapel Hill · USNorthShore University HealthSystem · US

Funding

Congestion Phenotypes and Splanchnic Nerve Modulation in Chronic Heart FailureK23HL151744 · NHLBI · DUKE UNIVERSITY · PI FUDIM, MARAT · 2021 to 2022
$376k
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS K23 HL151744NIH HHS HHSN268201700001INIH HHS HHSN268201700002INIH HHS HHSN268201700003INIH HHS HHSN268201700004INIH HHS HHSN268201700005I
6 · The paper itself

Abstract

aimsWe aimed to investigate the impact of obstructive coronary artery disease (CAD) in patients with acute decompensated heart failure (ADHF), and examine potential differences in prognostic utility for heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). METHODS AND

resultsThe Atherosclerosis Risk in Communities study conducted hospital surveillance of ADHF from 2005 to 2014. Obstructive CAD was defined as ≥50% or ≥75% stenosis, respectively, for the left main and other major epicardial arteries. Adjusted associations between obstructive CAD and 30-, 60-, and 90-day mortality were analysed. A total of 934 (4146 weighted) patients admitted with ADHF (mean age 72 years, 46% women, 30% Black, 30% HFpEF) had available angiography (61% performed in hospital). Obstructive CAD was more prevalent with HFrEF than HFpEF, whether at the left main (15% vs. 11%), left anterior descending (LAD) (48% vs. 30%), left circumflex (37% vs. 32%), right coronary (42% vs. 32%), or multiple coronary arteries (45% vs. 33%). In-hospital revascularization was performed in 25% and 22% of patients with HFrEF and HFpEF, respectively. Obstructive CAD was associated with higher adjusted mortality, particularly with left main or LAD involvement, and had a more pronounced association with 90-day mortality in HFrEF (odds ratio [OR] 2.77; 95% confidence interval [CI] 1.53-5.02) than HFpEF (OR 0.94; 95% CI 0.36-2.41) (p-interaction = 0.05).

conclusionPatients hospitalized with ADHF and coexisting obstructive CAD have higher short-term mortality, warranting the need for effective interventions and secondary prevention.

Indexed as

Coronary Artery DiseaseHeart FailureAgedFemaleHumansMalePrognosisStroke VolumeAcute heart failureHeart failure with preserved ejection fractionHeart failure with reduced ejection fractionObstructive coronary artery disease

Identifiers

PMID35851711
PMCPMC12366727
OpenAlexW4285802570

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.