Evidence map›Paper›PMID 35851698›Full record

ArticleThe Medical journal of Australia2022

COVID-19 in New South Wales children during 2021: severity and clinical spectrum.

Phoebe Williams, Archana Koirala, Gemma L Saravanos, Laura K Lopez, Catherine Glover, Ketaki Sharma, Tracey Williams, Emma Carey, Nadine Shaw, Emma Dickens and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Medical journal of Australia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Phoebe WilliamsThe Children's Hospital at Westmead, Sydney, NSW.
Archana KoiralaThe University of Sydney, Sydney, NSW.ORCID 0000-0002-2567-8825
Gemma L SaravanosKids Research, the Sydney Children's Hospitals Network, Sydney, NSW.ORCID 0000-0003-0040-6679
Laura K LopezNational Centre for Immunisation Research and Surveillance, the Children's Hospital at Westmead, Sydney, NSW.
Catherine GloverNational Centre for Immunisation Research and Surveillance, the Children's Hospital at Westmead, Sydney, NSW.
Ketaki SharmaThe University of Sydney, Sydney, NSW.
Tracey WilliamsThe Children's Hospital at Westmead, Sydney, NSW.
Emma CareyKids Research, the Sydney Children's Hospitals Network, Sydney, NSW.
Nadine ShawvirtualKIDS, the Sydney Children's Hospitals Network, Sydney, NSW.
Emma DickensvirtualKIDS, the Sydney Children's Hospitals Network, Sydney, NSW.
Neela SitaramvirtualKIDS, the Sydney Children's Hospitals Network, Sydney, NSW.
Joanne GingvirtualKIDS, the Sydney Children's Hospitals Network, Sydney, NSW.
Paula BrayKids Research, the Sydney Children's Hospitals Network, Sydney, NSW.
Nigel W CrawfordSurveillance of Adverse Events Following Vaccination in the Community (SAEFVIC), Murdoch Children's Research Institute, Melbourne, VIC.
Brendan McMullanRoyal Children's Hospital Melbourne, Melbourne, VIC.
Kristine MacartneyThe University of Sydney, Sydney, NSW.ORCID 0000-0002-4675-0232
Nicholas WoodThe Children's Hospital at Westmead, Sydney, NSW.
Elizabeth L FultonThe Children's Hospital at Westmead, Sydney, NSW.
Christine LauvirtualKIDS, the Sydney Children's Hospitals Network, Sydney, NSW.
Philip N BrittonThe Children's Hospital at Westmead, Sydney, NSW.ORCID 0000-0002-2993-6000
Sydney Children’s Hospitals Network · AUChildren's Hospital at Westmead · AUThe University of Sydney · AURoyal Children's Hospital · AU

Funding

Australian Commonwealth Department of HealthNational Health and Medical Research CouncilNSW Ministry of Health
6 · The paper itself

Abstract

objectivesTo describe the severity and clinical spectrum of coronavirus disease 2019 (COVID-19) in children during the 2021 New South Wales outbreak of the Delta variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). DESIGN,

settingProspective cohort study in three metropolitan Sydney local health districts, 1 June - 31 October 2021.

participantsChildren under 16 years of age with positive SARS-CoV-2 nucleic acid test results admitted to hospital or managed by the Sydney Children's Hospital Network (SCHN) virtual care team.

main outcome measuresAge-specific SARS-CoV-2 infection frequency, overall and separately for SCHN virtual and hospital patients; rates of medical and social reason admissions, intensive care admissions, and paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 per 100 SARS-CoV-2 infections; demographic and clinical factors that influenced likelihood of hospital admission.

resultsA total of 17 474 SARS-CoV-2 infections in children under 16 were recorded in NSW, of whom 11 985 (68.6%) received SCHN-coordinated care, including 459 admitted to SCHN hospitals: 165 for medical reasons (1.38 [95% CI, 1.17-1.59] per 100 infections), including 15 admitted to intensive care, and 294 (under 18 years of age) for social reasons (2.45 [95% CI, 2.18-2.73] per 100 infections). In an analysis that included all children admitted to hospital and a random sample of those managed by the virtual team, having another medical condition (adjusted odds ratio [aOR], 7.42; 95% CI, 3.08-19.3) was associated with increased likelihood of medical admission; in univariate analyses, non-asthmatic chronic respiratory disease was associated with greater (OR, 9.21; 95% CI, 1.61-174) and asthma/viral induced wheeze with lower likelihood of admission (OR, 0.38; 95% CI, 0.18-0.78). The likelihood of admission for medical reasons declined from infancy to 5-11 years, but rose again for those aged 12-15 years. Sex and Indigenous status did not influence the likelihood of admission.

conclusionMost SARS-CoV-2 infections (Delta variant) in children were asymptomatic or associated with mild disease. Hospitalisation was relatively infrequent, and most common for infants, adolescents, and children with other medical conditions. More children were hospitalised for social than for medical reasons.

Indexed as

COVID-19Nucleic AcidsAdolescentChildHospitalizationHumansInfantNew South WalesPandemicsProspective StudiesSARS-CoV-2Systemic Inflammatory Response SyndromeNucleic AcidsChildhood diseasesCOVID-19EpidemicsHome care services, hospital-basedMorbidity

Identifiers

PMID35851698
PMCPMC9349636
OpenAlexW4285803584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.