Evidence map›Paper›PMID 35851620›Full record

ArticleCommunications biology2022

Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy.

Yingli Gu, Flora Guerra, Mingzheng Hu, Alexander Pope, Kijung Sung, Wanlin Yang, Simone Jetha, Thomas A Shoff, Tessanya Gunatilake, Owen Dahlkamp and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Role of the Intermediate Filament Protein Peripherin in Health and Disease.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Yingli GuDepartment of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA.ORCID 0000-0002-5249-3535
Flora Guerra *Department of Biological and Environmental Sciences and Technologies (DiSTeBA), Università del Salento, Via Provinciale Lecce-Monteroni n. 165, 73100, Lecce, Italy.
Mingzheng Hu *Department of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA.
Alexander Pope *Department of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA.
Kijung SungDepartment of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA.
Wanlin YangDepartment of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA.
Simone JethaDepartment of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA.
Thomas A ShoffDepartment of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA.
Tessanya GunatilakeDepartment of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA.
Owen DahlkampDepartment of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA.
Linda Zhixia ShiDepartment of Bioengineering, University of California San Diego, La Jolla, 92093, CA, USA.
Fiore ManganelliDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Via Sergio Pansini 5, 80131, Naples, Italy.
Maria NolanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Via Sergio Pansini 5, 80131, Naples, Italy.
Yue ZhouSchool of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, China.ORCID 0000-0003-1524-7543
Jianqing DingInstitute of Neurology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Cecilia BucciDepartment of Biological and Environmental Sciences and Technologies (DiSTeBA), Università del Salento, Via Provinciale Lecce-Monteroni n. 165, 73100, Lecce, Italy. cecilia.bucci@unisalento.it.ORCID 0000-0002-6232-6183
Chengbiao WuDepartment of Neurosciences, University of California San Diego, La Jolla, 92093, CA, USA. chw049@health.ucsd.edu.ORCID 0000-0002-3660-088X
University of California San Diego · USShanghai Jiao Tong University · CNUniversity of Naples Federico II · ITUniversity of Salento · ITHarbin Medical University · CN

Funding

Project 3: TRiC modulation of CNS pathogenesis in HD mouse modelsP01NS092525 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMPSON, LESLIE MICHELS · 2016 to 2020
$6.3M
NINDS NIH HHS P01 NS092525
6 · The paper itself

Abstract

Rab7 GTPase regulates mitochondrial morphology and function. Missense mutation(s) of Rab7 underlies the pathogenesis of Charcot Marie Tooth 2B (CMT2B) peripheral neuropathy. Herein, we investigate how mitochondrial morphology and function are impacted by the CMT2B associated Rab7

Indexed as

Charcot-Marie-Tooth Diseaserab GTP-Binding ProteinsHumansLaminopathiesMitochondriarab7 GTP-Binding ProteinsSensory Receptor Cellsrab7 GTP-Binding Proteinsrab GTP-Binding Proteins

Identifiers

PMID35851620
PMCPMC9293960
OpenAlexW4285730085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.