ArticleNature cell biology2022
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16
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Article in Nature cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 58 citations in OpenAlex.
- Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications.Journal of hematology & oncology · 2026Review
- Stress granules and RNA-binding proteins in cellular senescence: a modular perspective on stress adaptation and inflammation.Molecular biology reports · 2026Review
- Review
- Uncovering a role for METTL13 in malignant transformation of human hematopoietic stem cells and in the progression of pediatric leukemia.Cell death & disease · 2026Article
- Review
- α-Ketoglutarate dictates AMPK protein synthesis for energy sensing in human cancers.Nature chemical biology · 2026Article
- Identification of ADAR1i-124: The first effective A-to-I RNA editing inhibitor with promising cancer therapeutic potential.iScience · 2026Article
- Propofol addiction drives neuronal senescence and cognitive decline via autophagy-mediated ADAR1/SIRT1 disruption.Communications biology · 2025Article
- Luteoloside alleviates bleomycin-induced pulmonary fibrosis in mice via SIRT1-mediated protective effect against alveolar epithelial cell senescence.Scientific reports · 2025Article
- Identification and Molecular Mechanism of Anti-Aging Low-Molecular-Weight Peptides from Quinoa Bran.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Article
- Uncovering a role for METTL13 in malignant transformation of human hematopoietic stem cells and in the progression of pediatric leukemia.Research square · 2025Article
- A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammation.Nature communications · 2025Article
- [ADAR1 Regulates the ERK/c-FOS/MMP-9 Pathway to Drive the Proliferation and Migration of Non-small Cell Lung Cancer Cells].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Article
- Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- METTL13 Promotes Pre-Leukemic Transformation and the Development of Pediatric Leukemia.bioRxiv : the preprint server for biology · 2025Article
- The kinase GSK-3 alters the RNA-binding protein landscape of lipid metabolism transcripts leading to altered expression in the C. elegans nervous system.Nucleic acids research · 2025Article
- Resveratrol Alleviates Arsenic Exposure-Induced Liver Fibrosis in Rats by Inhibiting Hepatocyte Senescence.Biological trace element research · 2025Article
- ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation.Nature communications · 2025Article
- Unleashing viral mimicry: A combinatorial strategy to enhance the efficacy of PARP7 inhibitors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- mTOR-related linc-PMB promotes mitochondrial biogenesis via stabilizing SIRT1 mRNA through binding to the HuR protein.Acta biochimica et biophysica Sinica · 2025Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 3 countries.
Xue HaoImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4138-1447
Yusuke ShiromotoGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5984-1726
Masayuki SakuraiGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6920-1746
Martina TowersImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Qiang ZhangGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Shuai WuGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Aaron HavasSanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.
Lu WangPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8896-0115
Shelley BergerPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5398-4400
Peter D AdamsSanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-0684-1770
Bin TianGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8903-8256
Kazuko NishikuraGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Andrew V KossenkovGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Pingyu LiuImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA. pingyu_liu@fudan.edu.cn.ORCID http://orcid.org/0000-0002-0498-1235
Rugang ZhangImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA. rzhang@wistar.org.ORCID http://orcid.org/0000-0002-7255-2360
The Wistar Institute · USSanford Burnham Prebys Medical Discovery Institute · USUniversity of Pennsylvania · US
Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MSTRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2008 to 2022
$28.3MSTRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASER01GM040536 · NIGMS · WISTAR INSTITUTE · PI NISHIKURA, KAZUKO · 1991 to 2021
$8.1MRegulation of Alternative Cleavage and PolyadenylationR01GM084089 · NIGMS · WISTAR INSTITUTE · PI TIAN, BIN · 2008 to 2023
$6.7MRole of BRCA1 Pathway in Regulating Oncogene-Induced SenescenceR01CA160331 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2012 to 2021
$4.0MRegulation of tumor recurrence by stress activated neutrophilsR01CA243142 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2020 to 2025
$2.8MIntegrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6MRegulation and Functions of 3'UTRs in Cellular StressR01GM129069 · NIGMS · WISTAR INSTITUTE · PI TIAN, BIN · 2018 to 2021
$1.5MStress Response Functions of ADAR1 Regulated by MAP KinasesR01GM130716 · NIGMS · WISTAR INSTITUTE · PI NISHIKURA, KAZUKO · 2019 to 2022
$1.5MCancer Targets and Drug DiscoveryT32CA211036 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI COSFORD, NICHOLAS DAVID · 2018 to 2022
$1.2MPurchase of an Echo 650 acoustic liquid handler with Access workstationS10OD030245 · OD · WISTAR INSTITUTE · PI SALVINO, JOSEPH M · 2021 to 2021
$567kNCI NIH HHS P30 CA010815NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA160331NCI NIH HHS R01 CA243142NCI NIH HHS R50 CA211199NCI NIH HHS T32 CA211036NIA NIH HHS K99 AG065500NIA NIH HHS P01 AG031862NIGMS NIH HHS R01 GM040536NIGMS NIH HHS R01 GM084089NIGMS NIH HHS R01 GM129069NIGMS NIH HHS R01 GM130716NIH HHS S10 OD030245
Abstract
Cellular senescence plays a causal role in ageing and, in mice, depletion of p16
Indexed as
Adenosine DeaminaseCyclin-Dependent Kinase Inhibitor p16AnimalsAutophagyCellular SenescenceDown-RegulationFemaleHumansMiceRNA EditingRNA, MessengerRNA Processing, Post-TranscriptionalSirtuin 1ADAR1 protein, mouseAdenosine DeaminaseCdkn2a protein, mouseCyclin-Dependent Kinase Inhibitor p16RNA, MessengerSirtuin 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.