Evidence map›Paper›PMID 35851607›Full record

ArticlePediatrics2022

Variation and Temporal Trends in Delivery Room Management of Moderate and Late Preterm Infants.

Sara C Handley, Elizabeth G Salazar, Lucy T Greenberg, Elizabeth E Foglia, Scott A Lorch, Erika M Edwards

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01825499 (Vermont Oxford Network Very Low Birth Weight Database of Infants <=1500 Grams or <=29 Weeks Gestational Age at Birth), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01825499 recruitingnot on this map

Vermont Oxford Network Very Low Birth Weight Database of Infants <=1500 Grams or <=29 Weeks Gestational Age at Birth

Typeobservational_patient_registrySponsorVermont Oxford NetworkRan1990 to 2040Enrolled60,000ConditionsNeonatologyArmsRegistry
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Observational
  4. Article
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sara C HandleyDivision of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Elizabeth G SalazarDivision of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Lucy T GreenbergVermont Oxford Network, Burlington, Vermont.
Elizabeth E FogliaDivision of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Scott A LorchDivision of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Erika M EdwardsVermont Oxford Network, Burlington, Vermont.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USUniversity of Vermont · USVermont Oxford Network · US

Funding

Training in Critical Care Health Policy ResearchT32HL098054 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Scott D Halpern · 2010 to 2026
$8.2M
Optimizing Respiratory Function in Delivery Room Resuscitation: The INFLATE Study (INFant Lung Aeration during Transition Events)K23HD084727 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI FOGLIA, ELIZABETH · 2016 to 2020
$809k
NHLBI NIH HHS T32 HL098054NICHD NIH HHS K23 HD084727
6 · The paper itself

Abstract

backgroundAlthough delivery room (DR) intervention decreases with increasing gestational age (GA), little is known about DR management of moderate and late preterm (MLP) infants.

methodsUsing the Vermont Oxford Network database of all NICU admissions, we examined the receipt of DR interventions including supplemental oxygen, positive pressure ventilation, continuous positive airway pressure, endotracheal tube ventilation, chest compressions, epinephrine, and surfactant among MLP infants (30 to 36 weeks') without congenital anomalies born from 2011 to 2020. Pneumothorax was examined as a potential resuscitation-associated complication. Intervention frequency was assessed at the infant- and hospital-level, stratified by GA and over time.

resultsOverall, 55.3% of 616 110 infants (median GA: 34 weeks) from 483 Vermont Oxford Network centers received any DR intervention. Any DR intervention frequency decreased from 89.7% at 30 weeks to 44.2% at 36 weeks. From 2011 to 2020, there was an increase in the provision of continuous positive airway pressure (17.9% to 47.8%, P ≤.001) and positive pressure ventilation (22.9% to 24.9%, P ≤.001) and a decrease in endotracheal tube ventilation (6.9% to 4.0% P ≤.001), surfactant administration (3.5% to 1.3%, P ≤.001), and pneumothorax (1.9% to 1.6%, P ≤.001). Hospital rates of any DR intervention varied (median 54%, interquartile range 47% to 62%), though the frequency was similar across hospitals with different NICU capabilities after adjustment.

conclusionsThe DR management of MLP infants varies at the individual- and hospital-level and is changing over time. These findings illustrate the differing interpretation of resuscitation guidelines and emphasize the need to study MLP infants to improve evidence-based DR care.

Indexed as

PneumothoraxPulmonary SurfactantsContinuous Positive Airway PressureDelivery RoomsFemaleGestational AgeHumansInfant, NewbornInfant, PrematurePregnancySurface-Active AgentsPulmonary SurfactantsSurface-Active Agents

Identifiers

PMID35851607
PMCPMC9721105
OpenAlexW4286220012

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.