Observational studyNeurology2022
Natural History Study of STXBP1-Developmental and Epileptic Encephalopathy Into Adulthood.
Erratum issuedOpen access · hybridAbstract readObservational Study
In one paragraph
Observational study in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Beyond Seizure Management in a Developmental Epileptic Encephalopathy: Expanding the SLC6A1 Neurodevelopmental Disorder Phenotype.Neurology. Genetics · 2026Article
- Associations of Cortical and Subcortical White Matter Morphometric Abnormalities With Clinical and Genetic Findings inNeurology. Genetics · 2026Article
- PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairment.Molecular psychiatry · 2026Article
- STXBP1 Variants Associated With Epilepsy With Variable Severity.CNS neuroscience & therapeutics · 2026Article
- Movement Disorders in Developmental and Epileptic Encephalopathies.Movement disorders clinical practice · 2026Review
- Epilepsy: Bridging Epidemiological Landscapes, Molecular Mechanisms, and Emerging Precision Therapeutics.Neuropsychiatric disease and treatment · 2026Review
- Evaluation, Diagnosis, and Treatment of Concomitant Movement Disorders in Genetic Epilepsies.Epilepsy currents · 2025Review
- Long-term outcomes of a cohort of patients with pharmacoresistant neonatal epilepsy and negative brain MRI.Epilepsia open · 2025Article
- Early mortality in STXBP1-related disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- 'You constantly have to be switched on': A qualitative interview study of parents of children with STXBP1-related disorders in the Netherlands.Orphanet journal of rare diseases · 2025Article
- STXBP1 Syndrome: Biotechnological Advances, Challenges, and Perspectives in Gene Therapy, Experimental Models, and Translational Research.Biotech (Basel (Switzerland)) · 2025Review
- Adult phenotypes of genetic developmental and epileptic encephalopathies.Brain communications · 2025Article
- Construction of a diagnostic model for temporal lobe epilepsy using interpretable deep learning: disease-associated markers identification.Frontiers in artificial intelligence · 2025Article
- Quantitative EEG biomarkers for STXBP1-related disorders.Epilepsia · 2024Article
- Adult Phenotype ofNeurology. Genetics · 2024Article
- Microcircuit failure in STXBP1 encephalopathy leads to hyperexcitability.Cell reports. Medicine · 2023Article
- Review
- Delineating clinical and developmental outcomes in STXBP1-related disorders.Brain : a journal of neurology · 2023Article
- Severity of GNAO1-Related Disorder Correlates with Changes in G-Protein Function.Annals of neurology · 2023Observational
- Applications for Deep Learning in Epilepsy Genetic Research.International journal of molecular sciences · 2023Review
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
41 authors at 1 institution in 2 countries.
Hannah StambergerFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia. hannah.stamberger@uantwerpen.be.
David CrosiersFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Ganna BalaguraFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0003-0212-8318
Claudia M BonardiFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-6266-3665
Anna BasuFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Gaetano CantalupoFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0003-1343-8434
Valentina ChiesaFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Jakob ChristensenFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-9385-6435
Bernardo Dalla BernardinaFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Colin A EllisFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Francesca FuriaFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Fiona GardinerFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Camille GironFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Renzo GuerriniFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-7272-7079
Karl Martin KleinFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Christian KorffFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Hana KrijtovaFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Melanie LefflerFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0003-1344-5554
Holger LercheFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-1783-8710
Gaetan LescaFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
David Lewis-SmithFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-1735-8178
Carla MariniFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-9212-2691
Dragan MarjanovicFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Laure MazzolaFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Sarah McKeown RuggieroFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Fanny MochelFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Francis RamondFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0003-4540-8096
Philipp S ReifFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Aurélie Richard-MornasFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Felix RosenowFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-3989-7471
Christian SchroppFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Rhys H ThomasFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0003-2062-8623
Aglaia VignoliFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0003-4638-4663
Yvonne WeberFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.
Elizabeth PalmerFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0003-1844-215X
Ingo HelbigFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0001-8486-0558
Ingrid E SchefferFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-2311-2174
Pasquale StrianoFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-6065-1476
Rikke S MøllerFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-9664-1448
Elena GardellaFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0002-7138-6022
Sarah WeckhuysenFrom the Applied and Translational Neurogenomics Group (H.S., S.W.), VIB Center for Molecular Neurology, University of Antwerp; Department of Neurology (H.S., D.C., S.W.), Antwerp University Hospital; Faculty of Medicine and Health Sciences (D.C., S.W.), Translational Neurosciences, Institute Born-Bunge (D.C.), and µNEURO Research Centre of Excellence (D.C., S.W.), University of Antwerp, Belgium; IRCCS Istituto Giannina Gaslini (G.B., P.S.), Genova; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (G.B., P.S.), University of Genova, Italy; Department of Epilepsy Genetics (C.M.B., F.F., R.S.M., E.G.), Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Department of Woman's and Child's Health (C.M.B.), Padova University Hospital, Italy; Population Health Sciences Institute (A.B.), Newcastle University; Department of Paediatric Neurology (A.B.), Newcastle upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neuropsychiatry Section (G.C.), Department of Surgical Sciences, Dentistry, Gynecology and Paediatrics, University of Verona; UOC Neuropsichiatria Infantile (G.C.), Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria Integrata, Verona; Center for Research on Epilepsies in Pediatric Age (CREP) (G.C., B.D.B.), Verona; Epilepsy Center (V.C.), ASST Santi Paolo Carlo, Milan, Italy; Department of Clinical Medicine (J.C.), Aarhus University; Department of Neurology (J.C.), Aarhus University Hospital, Denmark; Department of Neurology (C.A.E.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Regional Health Services Research (F.F., R.S.M., E.G.), University of Southern Denmark, Odense; University of Melbourne, Austin Health (F.G., I.E.S.), Victoria, Australia; AP-HP (C.G.), Pitié-Salpêtrière University Hospital, Department of Neurology, Paris, France; Child Neurology Unit and Laboratories (R.G.), Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy; Departments of Clinical Neurosciences (K.M.K.), Medical Genetics and Community Health Sciences, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada; Epilepsy Center Frankfurt Rhine-Main (K.M.K., P.S.R., F. Rosenow), Department of Neurology, Johann Wolfgang Goethe University; LOEWE Center for Personalized Translational Epilepsy Research (CePTER) (K.M.K., P.S.R., F. Rosenow), Goethe University Frankfurt, Frankfurt am Main, Germany; Pediatric Neurology Unit (C.K.), University Hospitals, Geneva, Switzerland; Department of Neurology (H.K.), Second Faculty of Medicine, Charles University and Motol University Hospital Prague, Czech Republic; The GOLD Service (M.L.), Waratah, New South Wales, Australia; Department of Neurology and Epileptology & Hertie Institute for Clinical Brain Research (H.L., Y.W.), University of Tubingen, Germany; Department of Medical Genetics (G.L.), Lyon University Hospital, Université de Lyon, INMG, France; Translational and Clinical Research Institute (D.L.-S., R.H.T.), Newcastle University; Department of Clinical Neurosciences (D.L.-S., R.H.T.), Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Child Neurology and Psychiatric Unit (C.M.), G. Salesi Pediatric Hospital, United Hospitals of Ancona, Italy; Department of Adults with Handicap (D.M.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Neurology (L.M.), University Hospital of St-Etienne; Team "Central Integration of Pain" (L.M.), Lyon Neuroscience Research Center, INSERM U 1028, CNRS UMR 5292, France; The Epilepsy NeuroGenetics Initiative (ENGIN) (S.M.R.), Children's Hospital of Philadelphia, PA; AP-HP (F.M.), Pitié-Salpêtrière University Hospital, Department of Genetics, Reference Centers for Adult Neurometabolic Diseases and Adult Leukodystrophies; INSERM U 1127 (F.M.), CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris Brain Institute, ICM; Service de Génétique (F. Ramond), Centre Hospitalier Universitaire de Saint-Etienne, France; Department of Neurology (P.S.R.), Ortenau Klinikum Offenburg Kehl, Germany; Unit of Neurophysiology and Epileptology (A.R.-M.), Hospices Civils of Lyon, France; Kinderklinik Dritter Orden (C.S.), Passau, Germany; Child Neuropsychiatry Unit (A.V.), Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, Italy; Department of Epileptology and Neurology (Y.W.), University of Aachen, Germany; School of Women and Children's Health (E.P.), Faculty of Medicine, UNSW; Sydney Children's Hospital Network (E.P.), Randwick, Australia; Division of Neurology (I.H.), Children's Hospital of Philadelphia, PA; and Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Florey and Murdoch Children's Research Institutes, Melbourne, Australia.ORCID 0000-0003-2878-1147
University of Antwerp · BE
Funding
ClinGen Expert Curation Panel for the EpilepsiesU24NS120854 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Ingo Helbig, HEATHER C. MEFFORD · 2021 to 2026
$2.0MPolygenic risk in familial epilepsyK23NS121520 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ELLIS, COLIN · 2021 to 2025
$1.1MJoint analysis of genomic and electronic medical record data to assess outcomes and drug response in pediatric epilepsiesK02NS112600 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI HELBIG, INGO · 2020 to 2024
$963kNINDS NIH HHS K02 NS112600NINDS NIH HHS K23 NS121520NINDS NIH HHS U24 NS120854
Abstract
BACKGROUND AND
objectivesPathogenic
methodsIn this observational study, patients with a minimum age of 18 years carrying a (likely) pathogenic
resultsThirty adult patients were included for summary statistics, with video recordings available for 19 patients. The median age at last follow-up was 24 years (range 18-58 years). All patients had epilepsy, with a median onset age of 3.5 months. At last follow-up, 80% of adults had treatment-resistant seizures despite long periods of seizure freedom in 37%. Tonic-clonic, focal, and tonic seizures were most frequent in adults. Epileptic spasms, an unusual feature beyond infancy, were present in 3 adults. All individuals had developmental impairment. Periods of regression were present in 59% and did not always correlate with flare-ups in seizure activity. Eighty-seven percent had severe or profound intellectual disability, 42% had autistic features, and 65% had significant behavioral problems. Video examinations showed gait disorders in all 12 patients able to walk, including postural abnormalities with external rotation of the feet, broad-based gait, and asymmetric posture/dystonia. Tremor, present in 56%, was predominantly of the intention/action type. Stereotypies were seen in 63%. Functional outcome concerning mobility was variable ranging from independent walking (50%) to wheelchair dependence (39%). Seventy-one percent of adults were nonverbal, and all were dependent on caregivers for most activities of daily living. DISCUSSION: STXBP1-DEE warrants continuous monitoring for seizures in adult life. Periods of regression are more frequent than previously established and can occur into adulthood. Movement disorders are often present and involve multiple systems. Although functional mobility is variable in adulthood, STXBP1-DEE frequently leads to severe cognitive impairments and a high level of functional dependence. Understanding the natural history of STXBP1-DEE is important for prognostication and will inform future therapeutic trials.
Indexed as
EpilepsyMovement DisordersMunc18 ProteinsActivities of Daily LivingAdolescentAdultElectroencephalographyHumansInfantMiddle AgedMutationSeizuresYoung AdultMunc18 ProteinsSTXBP1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.