Evidence map›Paper›PMID 35851507›Full record

Trial reportHuman psychopharmacology2022

High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.

David T Field, Rebekah O Cracknell, Jessica R Eastwood, Peter Scarfe, Claire M Williams, Ying Zheng, Teresa Tavassoli

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Human psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07469462 (An EEG Study to Investigate the Effect of High-dose Vitamin B6 Supplementation on Neural Activity in Relation to Depression and Anxiety Symptoms.), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07469462 narecruitingnot on this mapstarted 2026, after this paper: background citation

An EEG Study to Investigate the Effect of High-dose Vitamin B6 Supplementation on Neural Activity in Relation to Depression and Anxiety Symptoms.

TypeinterventionalSponsorUniversity of ReadingRan2026 to 2026Enrolled44ConditionsNeural Inhibition, Anxiety, DepressionArmsPyridoxal-5'-Phosphate supplement, Placebo Supplementation
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. High-dose Vitamin-B6 reduces sensory over-responsivity.Journal of psychopharmacology (Oxford, England) · 2024
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  10. Association between serum vitamin BThe British journal of nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David T FieldSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.ORCID 0000-0003-4041-8404
Rebekah O CracknellSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
Jessica R EastwoodSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
Peter ScarfeSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
Claire M WilliamsSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
Ying ZhengSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
Teresa TavassoliSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveVitamins B6 and B12 are involved in metabolic processes that decrease neural excitation and increase inhibition. This double-blind study investigated the effects of supplementation for 1 month with a high-dose of B6 or B12, compared to placebo, on a range of behavioural outcome measures connected to the balance between neural inhibition and excitation.

methods478 young adults were recruited over five linked phases. Self-reported anxiety (N = 265) and depression (N = 146) were assessed at baseline and after supplementation. Several sensory measures acted as assays of inhibitory function and were assessed post-supplementation only; these were surround suppression of visual contrast detection (N = 307), binocular rivalry reversal rate (N = 172), and a battery of tactile sensitivity tests (N = 180).

resultsVitamin B6 supplementation reduced self-reported anxiety and induced a trend towards reduced depression, as well as increased surround suppression of visual contrast detection, but did not reliably influence the other outcome measures. Vitamin B12 supplementation produced trends towards changes in anxiety and visual processing.

conclusionsOur results suggest that high-dose Vitamin B6 supplementation increases inhibitory GABAergic neural influences, which is consistent with its known role in the synthesis of GABA.

Indexed as

Dietary SupplementsVitamin B 6AnxietyCognitionFolic AcidHumansVitamin B 12Young AdultFolic AcidVitamin B 12Vitamin B 6anxietydepressionGABAsurround suppressionVitamin B12Vitamin B6

Identifiers

PMID35851507
PMCPMC9787829

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.