ArticleCerebral cortex (New York, N.Y. : 1991)2023
Familial and syndromic forms of arachnoid cyst implicate genetic factors in disease pathogenesis.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Extracranial Frontal Arachnoid Cyst in an Adult Patient: Case Report.Asian journal of neurosurgery · 2026Article
- Beyond mass effect: An age-stratified analysis of CSF circulation disturbance in symptomatic intracranial arachnoid cysts.Brain & spine · 2026Article
- A Comprehensive Review of Arachnoid Cysts.Cureus · 2025Review
- Examination of intracranial arachnoid cysts in children, symptomatic or asymptomatic.Current journal of neurology · 2024Article
- Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts.Nature medicine · 2023Article
- Controversies in the Treatment of Arachnoid Cysts with Special Emphasis on Temporal Arachnoid Cysts.Advances and technical standards in neurosurgery · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Arachnoid cysts (ACs) are the most common space-occupying lesions in the human brain and present significant challenges for clinical management. While most cases of ACs are sporadic, nearly 40 familial forms have been reported. Moreover, ACs are seen with increased frequency in multiple Mendelian syndromes, including Chudley-McCullough syndrome, acrocallosal syndrome, and autosomal recessive primary ciliary dyskinesia. These findings suggest that genetic factors contribute to AC pathogenesis. However, traditional linkage and segregation approaches have been limited in their ability to identify causative genes for ACs because the disease is genetically heterogeneous and often presents asymptomatically and sporadically. Here, we comprehensively review theories of AC pathogenesis, the genetic evidence for AC formation, and discuss a different approach to AC genomics that could help elucidate this perplexing lesion and shed light on the associated neurodevelopmental phenotypes seen in a significant subset of these patients.
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Registered trials
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