ArticleScientific reports2022
Branched-chain and aromatic amino acid levels response to an oral glucose load associated with gestational diabetes mellitus.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Plasma Amino Acid Responses to an Oral Glucose Challenge Relate More Strongly to Body Adiposity Than to Insulin Resistance.bioRxiv : the preprint server for biology · 2026Article
- Development and validation of a model integrating clinical and metabolomic markers for gestational diabetes mellitus prediction.Frontiers in medicine · 2026Article
- Effects of short-term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes.Experimental physiology · 2026Article
- Precision integrated identification of predictive first-trimester metabolomics signatures for early detection of gestational diabetes mellitus.Cardiovascular diabetology · 2025Article
- Serum Amino Acid Variations in Obesity and Gestational Diabetes During Pregnancy.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Article
- The association between circulating phenylalanine and the temporal risk of impaired insulin markers in gestational diabetes mellitus.Molecular genetics and metabolism reports · 2024Article
- Dietary intakes of methionine, threonine, lysine, arginine and histidine increased risk of type 2 diabetes in Chinese population: does the mediation effect of obesity exist?BMC public health · 2023Article
- Gut Microbiota and Critical Metabolites: Potential Target in Preventing Gestational Diabetes Mellitus?Microorganisms · 2023Review
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6 authors.
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Abstract
Serum branched chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with obesity, insulin resistance and type 2 diabetes mellitus (T2DM). We investigated the levels of these amino acids in women with gestational diabetes mellitus (GDM) and examined their changes in response to an oral glucose tolerance test (OGTT). 110 women were enrolled and underwent a 75-g OGTT during their second trimester; 43 women were diagnosed with GDM and 67 women did not have GDM (non-GDM women). During the OGTT, fasting, 1-h, and 2-h blood samples were obtained. BCAA and AAA levels were measured by liquid chromatography-tandem mass spectrometry. The differences in BCAA and AAA levels between GDM and non-GDM women were not evident during fasting but became significant after glucose loading. Glucose ingestion decreased the levels of BCAAs and AAAs in both groups. Notably, GDM women showed a delayed and blunted decrease in these amino acids compared to non-GDM women. The risks of 2-h changes in BCAAs and AAAs for GDM women were significant. We identified that the differences in BCAA and AAA levels between GDM women and controls, which were not evident during fasting, could be provoked by performing an OGTT.
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