Evidence map›Paper›PMID 35851002›Full record

ArticleCell death & disease2022

Monocytic myeloid-derived suppressive cells mitigate over-adipogenesis of bone marrow microenvironment in aplastic anemia by inhibiting CD8

Ying Qu, Zhengxu Sun, Yan Yuan, Zifeng Li, Fen Wang, Kunpeng Wu, Huihui Yu, Qiwang Lin, He Fei, Jian Chen and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Ying Qu *Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-5811-3065
Zhengxu Sun *Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China.
Yan Yuan *Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China.
Zifeng Li *Department of Hematology and Oncology, Children's Hospital, National Children's Medical Center, Fudan University, Shanghai, China.
Fen WangDepartment of Hematology, Huashan Hospital, Fudan University, Shanghai, China.
Kunpeng WuDepartment of Hematology, Huashan Hospital, Fudan University, Shanghai, China.
Huihui YuDepartment of Hematology, Huashan Hospital, Fudan University, Shanghai, China.
Qiwang LinDepartment of Gynecology, Obstetrics & Gynecology Hospital, Fudan University, Shanghai, China.
He FeiDepartment of Gynecology, Obstetrics & Gynecology Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-4686-4977
Jian ChenDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Maoxiang QianDepartment of Hematology and Oncology, Children's Hospital, National Children's Medical Center, Fudan University, Shanghai, China.
Yunfeng ChengDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China. yfcheng@fudan.edu.cn.ORCID 0000-0002-9581-1134
Hua JiangDepartment of Gynecology, Obstetrics & Gynecology Hospital, Fudan University, Shanghai, China. jianghua@fudan.edu.cn.ORCID 0000-0002-5235-341X
Tong ChenDepartment of Hematology, Huashan Hospital, Fudan University, Shanghai, China. chentong@fudan.edu.cn.ORCID 0000-0001-7895-2077
Fudan University · CNObstetrics and Gynecology Hospital of Fudan University · CNChildren's Hospital of Fudan University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aplastic anemia (AA) is a blood disorder resulted from over-activated T-cell related hematopoietic failure, with the characterization of hypocellularity and enhanced adipogenic differentiation of mesenchymal stroma cells (MSCs) in bone marrow (BM). However, little is known about the relationship between immune imbalance and polarized adipogenic abnormity of BM microenvironment in this disease entity. In the present study, we differentiated BM-MSCs into osteoblastic or adipogenic lineages to mimic the osteo-adipogenic differentiation. Activated CD8

Indexed as

Anemia, AplasticAdipogenesisAnimalsBone MarrowBone Marrow CellsCD8-Positive T-LymphocytesMice

Identifiers

PMID35851002
PMCPMC9293984
OpenAlexW4285736296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.