ArticleJACC. Cardiovascular imaging2022
Discordance Between Coronary Artery Calcium Area and Density Predicts Long-Term Atherosclerotic Cardiovascular Disease Risk.
Article in JACC. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Development and Validation of a Coronary Artery Calcium Volume and Density Score.Circulation. Cardiovascular imaging · 2026Article
- Coronary artery calcium scoring: expanding the new standard by photon-counting detector CT-Part I: Impact of tube voltage, tube current, slice thickness, and quantum iterative reconstructions.European radiology · 2026Article
- Associations between HIV serostatus and coronary artery plaque volume progression.AIDS (London, England) · 2025Observational
- Beyond the Agatston calcium score: role of calcium density and other calcified plaque markers for cardiovascular disease prediction.Current opinion in cardiology · 2025Review
- Improved Detection of Small and Low-Density Plaques in Virtual Noncontrast Imaging-based Calcium Scoring at Photon-Counting Detector CT.Radiology. Cardiothoracic imaging · 2024Article
- Left Main Coronary Artery Calcium and Diabetes Confer Very-High-Risk Equivalence in Coronary Artery Calcium >1,000.JACC. Cardiovascular imaging · 2024Article
- Artificial intelligence in coronary artery calcium score: rationale, different approaches, and outcomes.The international journal of cardiovascular imaging · 2024Review
- Advanced CT Imaging for the Assessment of Calcific Coronary Artery Disease and PCI Planning.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Review
- Thoracic Aortic Calcium Density and Area in Long-Term Atherosclerotic Cardiovascular Disease Risk Among Men Versus Women.Circulation. Cardiovascular imaging · 2023Article
- Radiation Dose Reduction for Coronary Artery Calcium Scoring Using a Virtual Noniodine Algorithm on Photon-Counting Detector Computed-Tomography Phantom Data.Diagnostics (Basel, Switzerland) · 2023Article
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16 authors at 10 institutions in 2 countries.
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Abstract
backgroundCoronary artery calcium (CAC) is commonly quantified as the product of 2 generally correlated measures: plaque area and calcium density.
objectivesThe authors sought to determine whether discordance between calcium area and density has long-term prognostic importance in atherosclerotic cardiovascular disease (ASCVD) risk.
methodsThe authors studied 10,373 primary prevention participants from the CAC Consortium with CAC >0. Based on their median values, calcium area and mean calcium density were divided into 4 mutually exclusive concordant/discordant groups. Cox proportional hazards regression assessed the association of calcium area/density groups with ASCVD mortality over a median of 11.7 years, adjusting for traditional risk factors and the Agatston CAC score.
resultsThe mean age was 56.7 years, and 24% were female. The prevalence of plaque discordance was 19% (9% low calcium area/high calcium density, 10% high calcium area/low calcium density). Female sex (odds ratio [OR]: 1.48 [95% CI: 1.27-1.74]) and body mass index (OR: 0.81 [95% CI: 0.76-0.87], per 5 kg/m
conclusionsFor a given CAC score, high calcium density relative to plaque area confers lower long-term ASCVD risk, likely serving as an imaging marker of biological resilience for lesion vulnerability. Additional research is needed to define a robust definition of calcium area/density discordance for routine clinical risk prediction.
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