Evidence map›Paper›PMID 35850732›Full record

ArticleMolecular autism2022

Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3

Natasha J Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C Watson, Anna K H Toft, Owen R Dando, Felicity H Inkpen, Paul S Baxter, Zrinko Kozić, Adam D Jackson and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular autism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Experimental Study: Youth vs. Life Experience of Adulthood in Terms of Acute Stress Response.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 3 countries.

Natasha J Anstey *Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Vijayakumar Kapgal *Centre for Brain Development and Repair, InStem, National Centre for Biological Sciences, Bangalore, Karnataka, 560065, India.
Shashank TiwariCentre for Brain Development and Repair, InStem, National Centre for Biological Sciences, Bangalore, Karnataka, 560065, India.
Thomas C WatsonCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Anna K H ToftCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Owen R DandoCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Felicity H InkpenCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Paul S BaxterCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Zrinko KozićCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Adam D JacksonCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Xin HeCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Mohammad Sarfaraz NawazCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Aiman KayenaatCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Aditi BhattacharyaCentre for Brain Development and Repair, InStem, National Centre for Biological Sciences, Bangalore, Karnataka, 560065, India.
David J A WyllieCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Sumantra ChattarjiCentre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Emma R Wood *Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Oliver Hardt *Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK.
Peter C Kind *Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, 5 George Square, Edinburgh, EH8 9XD, UK. p.kind@ed.ac.uk.ORCID 0000-0002-4256-9639
National Centre for Biological Sciences · INUniversity of Edinburgh · GBUK Dementia Research Institute · GB

Funding

Medical Research Council MR/P006213/1
6 · The paper itself

Abstract

backgroundMutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differences in fear response behaviours are often overlooked. We aim to examine fear behaviour and its cellular underpinnings in a rat model of ASD/ID lacking Nlgn3.

methodsThis study uses a range of behavioural tests to understand differences in fear response behaviour in Nlgn3

resultsWe observed that, unlike the wildtype, Nlgn3 LIMITATIONS: Our findings do not examine what specific cell type in the PAG is likely responsible for these phenotypes. Furthermore, we have focussed on phenotypes in young adult animals, whilst the human condition associated with NLGN3 mutations appears during the first few years of life.

conclusionsWe describe altered fear responses in Nlgn3

Indexed as

Autistic DisorderAnimalsFearFreezingHumansNeuronsPeriaqueductal GrayRatsAutismFearFlightFreezingIntellectual disabilityNeuroligin-3Periaqueductal grey

Identifiers

PMID35850732
PMCPMC9290228
OpenAlexW4285730137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.