Evidence map›Paper›PMID 35850596›Full record

ArticleJournal of investigative medicine high impact case reports

Catastrophic Neurological Complications in 2 Patients With Sickle Cell Disease and COVID-19.

Karen Clarke, Karima Benameur, Zanthia Wiley, Yoo Mee Shin, Mohamad Moussa, Fuad El Rassi, Morgan McLemore

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Karen ClarkeDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-5864-6814
Karima BenameurDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Zanthia WileyDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Yoo Mee ShinDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Mohamad MoussaDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Fuad El RassiDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Morgan McLemoreDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Emory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is commonly associated with neurological complications. Patients with sickle cell disease are at increased risk of developing neurologic complications throughout their lifetimes and often have underlying cardiopulmonary comorbidities that may predispose them to poor outcomes during serious infections. In this case series, we describe 2 patients with sickle cell disease who developed devastating neurologic complications following SARS-CoV-2 infection, which ultimately led to brain edema and death. We highlight the unusual manifestations of coronavirus disease 2019 in patients with sickle cell disease and address the risk of these patients to develop catastrophic neurologic injury due to COVID-19, if not recognized promptly.

Indexed as

Anemia, Sickle CellCOVID-19Nervous System DiseasesComorbidityHumansSARS-CoV-2COVID-19neurological complicationssickle cell

Identifiers

PMID35850596
PMCPMC9301110
OpenAlexW4285820995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.