ArticleBMC infectious diseases2022
The relationship between hematocrit and serum albumin levels difference and mortality in elderly sepsis patients in intensive care units-a retrospective study based on two large database.
Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 35 citations in OpenAlex.
- Prognostic value of hematological markers for anastomotic leakage diagnosed after postoperative day 5 following laparoscopic surgery for colorectal cancer.BMC surgery · 2026Article
- The association between hematocrit-albumin gap and sepsis risk in ICU patients: a multicenter cross-sectional study.Frontiers in medicine · 2026Article
- Knockoff-ML: a knockoff machine learning framework for controlled variable selection and risk stratification in electronic health record data.NPJ digital medicine · 2025Article
- Capillary leak syndrome in sepsis: the role of intrinsic coagulation pathway activation.BMC infectious diseases · 2025Article
- The predictive value of platelet parameters and hemorheological indicators for elderly sepsis patients.BMC anesthesiology · 2025Article
- Hemoglobin glycation index and neutrophil percentage as predictors of congestive heart failure among individuals diagnosed with sepsis: A MIMIC-IV cohort study.Scientific reports · 2025Article
- Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics.Cell death & disease · 2025Review
- A U shaped association between the HCT-ALB and hospital mortality in patients with sepsis.Scientific reports · 2025Observational
- Combined glycated hemoglobin index and red cell distribution width predict in-hospital mortality in critically ill sepsis patients based on MIMIC-IV analysis.Scientific reports · 2025Article
- A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia.iScience · 2025Article
- The difference in hematocrit and albumin levels and the risk of sepsis for patients with acute pancreatitis: a retrospective cohort study based on the MIMIC-IV database.Sao Paulo medical journal = Revista paulista de medicina · 2025Article
- Association of Hematocrit and Albumin Difference With Ventilator-Associated Pneumonia in Patients With Continuous Mechanical Ventilation: Evidence From MIMIC-IV Database.Canadian respiratory journal · 2025Article
- CT parameters of psoas muscle predicts 28-day mortality in older patients with sepsis: a retrospective study.BMC geriatrics · 2024Article
- Correlation of HCT-ALB, SmtO2, CRT and LAC with renal impairment and prognosis in patients with septic shock.Journal of medical biochemistry · 2024Article
- Association between hematocrit-to-albumin ratio and acute kidney injury in patients with acute pancreatitis: a retrospective cohort study.Scientific reports · 2024Article
- Article
- Predictive value of lactate/albumin ratio for death and multiple organ dysfunction syndrome in patients with sepsis.Journal of medical biochemistry · 2024Article
- Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 (MCP-1) and 28-Day Mortality in Elderly Patients with Sepsis: A Retrospective Single-Center Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Hematocrit and Albumin Levels at Admission Predict in-Hospital Mortality in Pediatric COVID-19 Omicron Variant Patients.Infection and drug resistance · 2024Article
- LASSO-Based Identification of Risk Factors and Development of a Prediction Model for Sepsis Patients.Therapeutics and clinical risk management · 2024Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSepsis still threatens the lives of more than 300 million patients annually and elderly patients with sepsis usually have a more complicated condition and a worse prognosis. Existing studies have shown that both Hematocrit (HCT) and albumin (ALB) can be used as potential predictors of sepsis, and their difference HCT-ALB has a significant capacity to diagnose infectious diseases. Currently, there is no relevant research on the relationship between HCT-ALB and the prognosis of elderly sepsis patients. Therefore, this study aims to explore the association between HCT-ALB and mortality in elderly patients with sepsis.
methodsThis study was a multi-center retrospective study based on the Medical Information Mart for Intensive Care (MIMIC-IV) database and the eICU Collaborative Research Database (eICU-CRD) in elderly patients with sepsis. The optimal HCT-ALB cut-off point for ICU mortality was calculated by the Youden Index based on the eICU-CRD dataset, and multivariate logistic regressions were conducted to explore the association between HCT-ALB and ICU/hospital mortality in the two databases. Subgroup analyses were performed for different parameters and comorbidity status.
resultsThe number of 16,127 and 3043 elderly sepsis patients were selected from two large intensive care databases (eICU-CRD and MIMIC-IV, respectively) in this study. Depending on the optimal cut-off point, patients in both eICU-CRD and MIMIC-IV were independently divided into low HCT-ALB (< 6.7) and high HCT-ALB (≥ 6.7) groups. The odds ratio (95%confidence interval) [OR (95CI%)] of the high HCT-ALB group were 1.50 (1.36,1.65) and 1.71 (1.58,1.87) for ICU and hospital mortality in the eICU-CRD database after multivariable adjustment. Similar trends in the ICU and hospital mortality [OR (95%CI) 1.41 (1.15,1.72) and 1.27 (1.07,1.51)] were observed in MIMIC-IV database. Subgroup analysis showed an interaction effect with SOFA score in the eICU-CRD database however not in MIMIC-IV dataset.
conclusionsHigh HCT-ALB (≥ 6.7) is associated with 1.41 and 1.27 times ICU and hospital mortality risk in elderly patients with sepsis. HCT-ALB is simple and easy to obtain and is a promising clinical predictor of early risk stratification for elderly sepsis patients in ICU.
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