Evidence map›Paper›PMID 35850532›Full record

ArticleHuman gene therapy2022

Scientists' Views on Scientific Self-Governance for Human Genome Editing Research.

R Jean Cadigan, Margaret Waltz, Gail E Henderson, John M Conley, Arlene M Davis, Rami Major, Eric T Juengst

Abstract read
In one paragraph

Article in Human gene therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

R Jean CadiganDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-6793-2174
Margaret WaltzDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Gail E HendersonDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
John M ConleyUniversity of North Carolina School of Law, Chapel Hill, North Carolina, USA.
Arlene M DavisDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Rami MajorCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Eric T JuengstDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
Incidental Enhancement: Addressing a Neglected Policy Issue in Human Genome EditingR01HG010661 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CADIGAN, ROSEMARY JEAN · 2020 to 2023
$3.1M
NHGRI NIH HHS R01 HG010661
6 · The paper itself

Abstract

As research on human gene editing has grown, a variety of prominent international organizations are considering how best to govern such research. But what role do scientists engaged in genome editing think they should have in developing research governance? In this study, we present results from a survey of 212 U.S.-based scientists regarding views on human genome editing governance. Most did not believe that scientists should be allowed to self-govern human genome editing research. Open-ended responses revealed four main reasons: conflicts of interest, the inevitability of rare "bad apples," historical evidence to the contrary, and the limitations of scientific expertise. Analyses of open-ended responses also revealed scientists' views on how human gene editing research should be governed. These views emphasize interdisciplinary professional and public input. The study results illustrate a noteworthy shift in the scientific community's traditional vision of professional autonomy and can inform ongoing efforts to develop research governance approaches.

Indexed as

Gene EditingGenome, HumanHumansSurveys and Questionnairesgene editinggovernanceoversightsurvey

Identifiers

PMID35850532
PMCPMC9700337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.