ArticleNature2022
Bacterial retrons encode phage-defending tripartite toxin-antitoxin systems.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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107citing papers in PubMed
24.4field-weighted citation impact, top 1% of its field
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Who cites it
107 citing papers in PubMed, 154 citations in OpenAlex.
- How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026Review
- Discovery and engineering of retrons for precise genome editing.Nature biotechnology · 2026Article
- Characterization of defensome genes and mobile genetic Elements in different types of pasture soil agroecosystems from the Brazilian Amazon.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Article
- Phage host range: determinants, dynamics and applications.Nature reviews. Microbiology · 2026Review
- Higher-order assembly of a type IX retron enables exploitation for designer antimicrobials.bioRxiv : the preprint server for biology · 2026Article
- A Type VII-secreted toxin enables inter-mycobacterial competition.Nature communications · 2026Article
- Mechanistic insights into activation of bacterial Retron-Eco8 immunity by phage protein SSB.Nature communications · 2026Article
- Construction of synthetic protein-binding non-genetic DNA systems in living cells.Nature chemistry · 2026Article
- Semirandom DNA adducts regulate a filamentous defense-associated reverse transcriptase.Nature structural & molecular biology · 2026Article
- Structural insights into the assembly and function of Retron Ec78 PtuAB.Communications biology · 2026Article
- Rapid Preparation of Electrocompetent Listeria monocytogenes and Enhancement of Transformation Efficiency with cAMP Supplementation.Journal of food protection · 2026Article
- Genome editing of phylogenetically distinct bacteria using cross-species retron-mediated recombineering.Nature biotechnology · 2026Article
- Periplasmic gatekeeping of phage DNA entry by an rSAM enzyme matured effector with HxS repeats.Nature communications · 2026Article
- Structural basis of Retron-Eco8-mediated antiphage defense.Nucleic acids research · 2026Article
- Structure and mechanism of antiphage retron Eco2.Nature structural & molecular biology · 2026Article
- Review
- [Research on Bacteriophage Resistance: Coevolutionary Arms Race Between Bacteria and Phages Drives Novel Antibacterial Therapies].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Bacterial defense systems: Mechanisms, homology to eukaryotic immune systems, and applications.Zoological research · 2026Review
- ChemGenXplore: an interactive tool for exploring and analysing chemical genomic data.Bioinformatics (Oxford, England) · 2026Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 10 institutions in 6 countries.
Jacob BobonisGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9293-9733
Karin Mitosch *Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
André Mateus *Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6870-0677
Nicolai KarcherStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
George KritikosGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1434-5176
Joel SelkrigGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Matylda ZietekGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Vivian MonzonEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK.
Birgit PfalzGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Sarela Garcia-SantamarinaGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Marco GalardiniInstitute for Molecular Bacteriology, TWINCORE Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
Anna SuekiGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Callie KobayashiDepartment of Microbial Pathogenesis and Immunology, Texas A&M University, College Station, TX, USA.
Frank SteinProteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9695-1692
Alex BatemanEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK.ORCID http://orcid.org/0000-0002-6982-4660
Georg ZellerStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1429-7485
Mikhail M SavitskiGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2011-9247
Johanna R ElfenbeinDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA. jelfenbein@wisc.edu.ORCID http://orcid.org/0000-0002-4764-0713
Helene L Andrews-PolymenisDepartment of Microbial Pathogenesis and Immunology, Texas A&M University, College Station, TX, USA. handrews@tamu.edu.ORCID http://orcid.org/0000-0002-1818-1335
Athanasios TypasGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. typas@embl.de.ORCID http://orcid.org/0000-0002-0797-9018
European Molecular Biology Laboratory · DEEuropean Bioinformatics Institute · GBEuropean Molecular Biology Laboratory · DEHeidelberg University · DEHospital of St. Francis Xavier · PTMedizinische Hochschule Hannover · DETexas A&M Health Science Center · USTexas A&M University · USUniversity of Basel · CHUniversity of Wisconsin–Madison · US
Funding
Functional dissection of the retron St-85 of Salmonella TyphimuriumK08AI108794 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ELFENBEIN, JOHANNA REBECCA · 2014 to 2017
$602kNIAID NIH HHS K08 AI108794
Abstract
Retrons are prokaryotic genetic retroelements encoding a reverse transcriptase that produces multi-copy single-stranded DNA
Indexed as
AntitoxinsBacteriophagesRetroelementsSalmonella typhimuriumToxin-Antitoxin SystemsDNA, BacterialDNA, Single-StrandedNucleic Acid ConformationProphagesRNA-Directed DNA PolymeraseAntitoxinsDNA, BacterialDNA, Single-StrandedRetroelementsRNA-Directed DNA Polymerase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.