Evidence map›Paper›PMID 35850120›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology2023

Recent advancements in single dose slow-release devices for prophylactic vaccines.

Sayoni Ray, Armando Puente, Nicole F Steinmetz, Jonathan K Pokorski

Open access · greenAbstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Global vaccine development.Nature medicine · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Vaccination status and main contributors to low vaccination coverage in five health regions in the state of Sergipe.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sayoni RayDepartment of NanoEngineering, University of California-San Diego, La Jolla, California, USA.
Armando PuenteDepartment of NanoEngineering, University of California-San Diego, La Jolla, California, USA.
Nicole F SteinmetzDepartment of NanoEngineering, University of California-San Diego, La Jolla, California, USA.ORCID 0000-0002-0130-0481
Jonathan K PokorskiDepartment of NanoEngineering, University of California-San Diego, La Jolla, California, USA.ORCID 0000-0001-5869-6942
Discovery Institute · USUniversity of California San Diego · US

Funding

mRNA COVID-19 Vaccines Delivered with Plant Virus/Polymer DevicesR21AI161306 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POKORSKI, JONATHAN KYLE, STEINMETZ, NICOLE FRANZISKA · 2021 to 2022
$435k
NIAID NIH HHS R21 AI161306
6 · The paper itself

Abstract

Single dose slow-release vaccines herald a new era in vaccine administration. An ideal device for slow-release vaccine delivery would be minimally invasive and self-administered, making these approaches an attractive alternative for mass vaccination programs, particularly during the time of a pandemic. In this review article, we discuss the latest advances in this field, specifically for prophylactic vaccines able to prevent infectious diseases. Recent studies have found that slow-release vaccines elicit better immune responses and often do not require cold chain transportation and storage, thus drastically reducing the cost, streamlining distribution, and improving efficacy. This promise has attracted significant attention, especially when poor patient compliance of the standard multidose vaccine regimes is considered. Single dose slow-release vaccines are the next generation of vaccine tools that could overcome most of the shortcomings of present vaccination programs and be the next platform technology to combat future pandemics. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Implantable Materials and Surgical Technologies > Nanomaterials and Implants Biology-Inspired Nanomaterials > Protein and Virus-Based Structures.

Indexed as

NanostructuresVaccinesDrug Delivery SystemsDrug DiscoveryHumansVaccinationVaccinescontrolled releaseimmune cell kineticsimplantmicroneedlemicroparticlePLGAprophylactic vaccinessingle doseslow releasevaccine deliveryvaccine kinetics

Identifiers

PMID35850120
PMCPMC9840709
OpenAlexW4285801055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.