ReviewBritish journal of clinical pharmacology2022
Identifying and addressing pill aversion in adults without physiological-related dysphagia: A narrative review.
Review in British journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Valbenazine Sprinkle: An Alternative Formulation of Valbenazine for Oral Administration in Patients With Dysphagia.Clinical and translational science · 2025Trial
- Relative bioavailability of fedratinib through various alternative oral administration methods in healthy adults.Cancer chemotherapy and pharmacology · 2024Trial
- Discriminating Isolated Pill Dysphagia from General Oropharyngeal Dysphagia: Psychometric Properties of the Turkish PILL-5.Dysphagia · 2026Article
- A qualitative study exploring the views of healthcare professionals regarding patients who have difficulty swallowing medicines.International journal of clinical pharmacy · 2026Article
- Extemporaneous Formulations for Pediatric Patients: Global Necessities, Challenges and Opportunities.Pharmaceutics · 2026Review
- Alternative Administration of Antiretroviral Therapy in People with HIV Unable to Swallow: A Scoping Review.HIV/AIDS (Auckland, N.Z.) · 2026Review
- Application of a screening tool to understand the medication habits of patients with swallowing difficulty: a prospective observational study.International journal of clinical pharmacy · 2025Observational
- Detection and management of pill swallowing difficulties: a community pharmacy-based observational study.International journal of clinical pharmacy · 2025Observational
- Understanding Treatment Adherence in Chronic Diseases: Challenges, Consequences, and Strategies for Improvement.Journal of clinical medicine · 2025Review
- Reaping the rewards of a simplified dosing regimen.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Knowledge, Attitudes, and Practices Regarding Swallowing Disorders Among General Practitioners.International journal of general medicine · 2025Article
- Ibrutinib oral suspension bioavailability and compatibility for optimal enteral administration route.Therapeutic advances in hematology · 2025Article
- Article
- Point Prevalence Survey of Acute Hospital Patients with Difficulty Swallowing Solid Oral Dose Forms.Pharmaceutics · 2024Article
- Preference for a Novel Oral Alternative to Parenterally Administered Medications.Patient preference and adherence · 2024Article
- Influence of Solid Oral Dosage Form Characteristics on Swallowability, Visual Perception, and Handling in Older Adults.Pharmaceutics · 2023Article
- Impact of Tablet Size and Shape on the Swallowability in Older Adults.Pharmaceutics · 2023Article
- KidzMed e-learning to upskill student pharmacists to teach pill swallowing to children.PloS one · 2023Article
- Identifying and addressing pill aversion in adults without physiological-related dysphagia: A narrative review.British journal of clinical pharmacology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solid oral dosage forms (SODFs) (often called pills by patients) are the default formulation to treat medical ailments. Beneficial therapeutic outcomes rely on patients taking them as directed. Up to 40% of the population experience difficulties swallowing SODFs, resulting in reduced adherence and impaired therapeutic efficacy. Often associated with children, this also presents in adults with dysphagia, and without any organic dysphagia (non-physiological-related or functional dysphagia). This review aims to identify and appraise current interventions used to screen for and overcome pill aversion in adults with functional dysphagia. A comprehensive search of the literature was conducted. Articles reporting pill aversion in adults aged ≥18 years with no underlying cause, history of, or existing dysphagia were included. Study quality was determined using the STROBE tool for observational studies. A narrative synthesis of the findings was prepared. We identified 18 relevant cohort studies, which demonstrate that pill aversion is a global problem. Perceived ease of and/or SODF swallowability appears to be influenced by female gender, younger age, co-morbidities (e.g., depression), and physical SODF properties. Patients often modify their medicines rather than raise this issue with their healthcare team. Screening for pill aversion is haphazard but controlled postural adjustments, coating SODFs and behavioural interventions appear to be successful solutions. SODF swallowing difficulties are a barrier to effective medication use. Healthcare professionals must recognise that pill aversion is a problem requiring identification through effective screening and resolution by training interventions, appropriate formulation selection or specialist referral.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.