Evidence map›Paper›PMID 35849656›Full record

ArticleAmerican journal of respiratory cell and molecular biology2022

WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.

Tayyab Rehman, Philip H Karp, Andrew L Thurman, Steven E Mather, Akansha Jain, Ashley L Cooney, Patrick L Sinn, Alejandro A Pezzulo, Michael E Duffey, Michael J Welsh

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Acquired CFTR dysfunction and dense distribution of ionocytes in nasal mucosa of children with CRS.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  4. Review
  5. A Nod and a WNK (Kinase): Understanding Airway Surface Liquid pH.American journal of respiratory cell and molecular biology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Tayyab RehmanDepartment of Internal Medicine and.ORCID 0000-0001-7792-201X
Philip H KarpDepartment of Internal Medicine and.
Andrew L ThurmanDepartment of Internal Medicine and.
Steven E MatherDepartment of Internal Medicine and.
Akansha JainDepartment of Internal Medicine and.
Ashley L CooneyDepartment of Pediatrics, Pappajohn Biomedical Institute.ORCID 0000-0003-2717-9138
Patrick L SinnDepartment of Pediatrics, Pappajohn Biomedical Institute.
Alejandro A PezzuloDepartment of Internal Medicine and.ORCID 0000-0001-7544-5109
Michael E DuffeyDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York.
Michael J WelshDepartment of Internal Medicine and.
Pulp and Paper Research Institute · SKUniversity of Iowa · USUniversity at Buffalo, State University of New York · US

Funding

Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
Pathology CoreP01HL152960 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2020 to 2024
$11.6M
Medical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4M
Epigenetic mechanisms of inflammatory memory propagation in human airway epitheliaR01HL163024 · NHLBI · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 2022 to 2026
$2.8M
Heat-shock protein 90 modulates goblet cell metaplasia in human airway epitheliaK01HL140261 · NHLBI · UNIVERSITY OF IOWA · PI PEZZULO, ALEJANDRO ANTONIO · 2019 to 2023
$746k
Howard Hughes Medical InstituteNHLBI NIH HHS K01 HL140261NHLBI NIH HHS K01HL140261NHLBI NIH HHS P01 HL091842NHLBI NIH HHS P01 HL152960NHLBI NIH HHS R01 HL163024NIDDK NIH HHS P30 DK054759NIGMS NIH HHS T32 GM139776NIH HHS HL091842
6 · The paper itself

Abstract

In cystic fibrosis (CF), reduced HCO

Indexed as

Cystic FibrosisAlanineBumetanideHumansHydrogen-Ion ConcentrationProlineProtein IsoformsProtein KinasesProtein Serine-Threonine KinasesSodium-Potassium-Chloride SymportersWNK Lysine-Deficient Protein Kinase 1AlanineBumetanideProlineProtein IsoformsProtein KinasesProtein Serine-Threonine KinasesSodium-Potassium-Chloride SymportersWNK1 protein, humanWNK2 protein, humanWNK Lysine-Deficient Protein Kinase 1airway surface liquidanion transportcystic fibrosispHWNK kinases

Identifiers

PMID35849656
PMCPMC9564924
OpenAlexW4285730413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.