Evidence map›Paper›PMID 35849531›Full record

ArticleJournal of proteome research2023

Rapid Multivariate Analysis Approach to Explore Differential Spatial Protein Profiles in Tissue.

Kavya Sharman, Nathan Heath Patterson, Andy Weiss, Elizabeth K Neumann, Emma R Guiberson, Daniel J Ryan, Danielle B Gutierrez, Jeffrey M Spraggins, Raf Van de Plas, Eric P Skaar and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. MALDI IMS-Derived Molecular Contour Maps: Augmenting Histology Whole-Slide Images.Journal of the American Society for Mass Spectrometry · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Kavya SharmanMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-3487-7199
Nathan Heath PattersonMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-0064-1583
Andy WeissDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, United States.
Elizabeth K NeumannMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-6078-3321
Emma R GuibersonMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-1579-7820
Daniel J RyanPfizer Inc., Chesterfield, Missouri 63017, United States.
Danielle B GutierrezMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-6355-2134
Jeffrey M SpragginsMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-9198-5498
Raf Van de PlasMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-2232-7130
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, United States.
Richard M CaprioliMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.
Vanderbilt University · USPfizer (United States) · USVanderbilt University Medical Center · US

Funding

TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human KidneyU54DK134302 · NIDDK · VANDERBILT UNIVERSITY · PI SPRAGGINS, JEFFREY M · 2022 to 2025
$7.1M
Pathobiology of heme inducible transporters in Gram positive pathogensR01AI073843 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2009 to 2025
$5.9M
Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue MappingU54DK120058 · NIDDK · VANDERBILT UNIVERSITY · PI HARRIS, RAYMOND C. · 2018 to 2021
$5.7M
Pancreas Organ Specific ProjectU54EY032442 · NEI · VANDERBILT UNIVERSITY · PI POWERS, ALVIN C, SCHEY, KEVIN L · 2020 to 2024
$5.7M
Mechanism and function of heme-iron utilization in staphylococcal pathogenesisR01AI069233 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2006 to 2020
$5.6M
Molecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometryR01AI138581 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric P Skaar, Jeffrey M Spraggins · 2018 to 2026
$5.2M
Defining the impact of host factors on the molecular architecture and bacterial physiology of Staphylococcus aureus abscessesR01AI145992 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASSAT, JAMES E, SKAAR, ERIC P · 2020 to 2024
$3.8M
Defining the molecular inventory of staphylococcal tissue abscesses and its effects on the host-pathogen interfaceF32AI157215 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WEISS, ANDY · 2021 to 2023
$145k
NEI NIH HHS U54 EY032442NIAID NIH HHS F32 AI157215NIAID NIH HHS R01 AI069233NIAID NIH HHS R01 AI073843NIAID NIH HHS R01 AI138581NIAID NIH HHS R01 AI145992NIDDK NIH HHS U54 DK120058NIDDK NIH HHS U54 DK134302NIEHS NIH HHS T32 ES007028
6 · The paper itself

Abstract

Spatially targeted proteomics analyzes the proteome of specific cell types and functional regions within tissue. While spatial context is often essential to understanding biological processes, interpreting sub-region-specific protein profiles can pose a challenge due to the high-dimensional nature of the data. Here, we develop a multivariate approach for rapid exploration of differential protein profiles acquired from distinct tissue regions and apply it to analyze a published spatially targeted proteomics data set collected from

Indexed as

CalciumProteomicsAnimalsComputational BiologyMiceMultivariate AnalysisProteomeCalciumProteomeabscess formationbioinformaticscomputational proteomicshost−pathogen interfacemachine learningmass spectrometrymicroLESAproteomicsspatially targeted proteomicsStaphylococcus aureus

Identifiers

PMID35849531
PMCPMC9845430
OpenAlexW4285728931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.