Evidence map›Paper›PMID 35849331›Full record

ReviewJournal of experimental botany2023

The small subunit of Rubisco and its potential as an engineering target.

Yuwei Mao, Ella Catherall, Aranzazú Díaz-Ramos, George R L Greiff, Stavros Azinas, Laura Gunn, Alistair J McCormick

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of experimental botany, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 60 citations in OpenAlex.

  1. Transfer of chloroplastSynthetic and systems biotechnology · 2027
    Article
  2. Article
  3. Review
  4. EnhancedMarine drugs · 2026
    Article
  5. Rubisco kinetic acclimation at the holoenzyme level.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Small subunit isoform diversity underlies structural heterogeneity in native plant Rubisco.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Rewinding evolution in planta: A Rubisco-null platform validates high-performance ancestral enzymes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Review
  11. Rubisco is slow across the tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Engineering COPlant communications · 2025
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Yuwei MaoSynthSys & Institute of Molecular Plant Sciences, School of Biological Sciences, King's Buildings, University of Edinburgh, Edingburgh EH9 3BF, UK.ORCID 0000-0002-7373-9071
Ella CatherallSynthSys & Institute of Molecular Plant Sciences, School of Biological Sciences, King's Buildings, University of Edinburgh, Edingburgh EH9 3BF, UK.ORCID 0000-0003-4581-5150
Aranzazú Díaz-RamosSynthSys & Institute of Molecular Plant Sciences, School of Biological Sciences, King's Buildings, University of Edinburgh, Edingburgh EH9 3BF, UK.ORCID 0000-0002-3773-5890
George R L GreiffSchool of Biological Sciences, University of Bristol, 24 Tyndall Avenue, Bristol BS8 1TQ, UK.ORCID 0000-0002-0965-2764
Stavros AzinasDepartment of Cell and Molecular Biology, Uppsala University, S-751 24 Uppsala, Sweden.ORCID 0000-0002-3744-9229
Laura GunnDepartment of Cell and Molecular Biology, Uppsala University, S-751 24 Uppsala, Sweden.ORCID 0000-0003-2072-0884
Alistair J McCormickSynthSys & Institute of Molecular Plant Sciences, School of Biological Sciences, King's Buildings, University of Edinburgh, Edingburgh EH9 3BF, UK.ORCID 0000-0002-7255-872X
University of Edinburgh · GBUppsala University · SEUniversity of Bristol · GB

Funding

Biotechnology and Biological Sciences Research Council BB/S015531/1
6 · The paper itself

Abstract

Rubisco catalyses the first rate-limiting step in CO2 fixation and is responsible for the vast majority of organic carbon present in the biosphere. The function and regulation of Rubisco remain an important research topic and a longstanding engineering target to enhance the efficiency of photosynthesis for agriculture and green biotechnology. The most abundant form of Rubisco (Form I) consists of eight large and eight small subunits, and is found in all plants, algae, cyanobacteria, and most phototrophic and chemolithoautotrophic proteobacteria. Although the active sites of Rubisco are located on the large subunits, expression of the small subunit regulates the size of the Rubisco pool in plants and can influence the overall catalytic efficiency of the Rubisco complex. The small subunit is now receiving increasing attention as a potential engineering target to improve the performance of Rubisco. Here we review our current understanding of the role of the small subunit and our growing capacity to explore its potential to modulate Rubisco catalysis using engineering biology approaches.

Indexed as

CyanobacteriaRibulose-Bisphosphate CarboxylaseCarbon DioxideCatalysisPhotosynthesisPlantsCarbon DioxideRibulose-Bisphosphate CarboxylaseAlgaecarboxylationoxygenationphotosynthesisplants

Identifiers

PMID35849331
PMCPMC9833052
OpenAlexW4285800179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.