Evidence map›Paper›PMID 35849291›Full record

ArticleAnnals of surgical oncology2022

Co-Localization of Gastrointestinal Stromal Tumors (GIST) and Peritoneal Mesothelioma: A Case Series.

Asimina S Courelli, Ashwyn K Sharma, Lisa Madlensky, Yoon Young Choi, Sam Li, Shirley Sarno, Kaitlyn Kelly, Winta Mehtsun, Santiago Horgan, Olivier Harismendy and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The Many Faces of the Angry Peritoneum.Diagnostics (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Asimina S CourelliDivision of Surgical Oncology, Department of Surgery, University of California, San Diego, CA, USA.
Ashwyn K SharmaDivision of Surgical Oncology, Department of Surgery, University of California, San Diego, CA, USA.
Lisa MadlenskyMoores Cancer Center, La Jolla, CA, USA.
Yoon Young ChoiDivision of Surgical Oncology, Department of Surgery, University of California, San Diego, CA, USA.
Sam LiDivision of Surgical Oncology, Department of Surgery, University of California, San Diego, CA, USA.
Shirley SarnoDivision of Surgical Oncology, Department of Surgery, University of California, San Diego, CA, USA.
Kaitlyn KellyDivision of Surgical Oncology, Department of Surgery, University of California, San Diego, CA, USA.
Winta MehtsunDivision of Surgical Oncology, Department of Surgery, University of California, San Diego, CA, USA.
Santiago HorganSchool of Medicine, University of California, San Diego, CA, USA.
Olivier HarismendyMoores Cancer Center, La Jolla, CA, USA.
Joel M BaumgartnerDivision of Surgical Oncology, Department of Surgery, University of California, San Diego, CA, USA.
Jason K SicklickDivision of Surgical Oncology, Department of Surgery, University of California, San Diego, CA, USA. jsicklick@health.ucsd.edu.
University of California, San Diego · USMoores Cancer CenterCenter for Special Minimally Invasive and Robotic Surgery · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
UCSD Cancer Center Training Program in Drug DevelopmentT32CA121938 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Bouvet, Dwayne G. Stupack · 2006 to 2026
$10.3M
Targeting Drug-Resistant Cancer Stem Cell Niches of Gastrointestinal Stromal TumorR01CA226803 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2019 to 2023
$2.1M
NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA226803NCI NIH HHS T32 CA121938
6 · The paper itself

Abstract

purposeGastrointestinal stromal tumor (GIST) is associated with increased risk of additional cancers. In this study, synchronous GIST, and peritoneal mesothelioma (PM) were characterized to evaluate the relationship between these two cancers.

methodsA retrospective chart review was conducted for patients diagnosed with both GIST and PM between July 2010 and June 2021. Patient demographics, past tumor history, intraoperative reports, cross-sectional imaging, peritoneal cancer index (PCI) scoring, somatic next-generation sequencing (NGS) analysis, and histology were reviewed.

resultsOf 137 patients who underwent primary GIST resection from July 2010 to June 2021, 8 (5.8%) were found to have synchronous PM, and 4 patients (50%) had additional cancers and/or benign tumors. Five (62.5%) were male, and the median age at GIST diagnosis was 57 years (range: 45-76). Seventy-five percent of GISTs originated from the stomach. Of the eight patients, one patient had synchronous malignant mesothelioma (MM), and the remaining had well-differentiated papillary mesothelioma (WDPM), which were primarily located in the region of the primary GIST (89%). The median PCI score was 2 in the WDPM patients. NGS of GIST revealed oncogenic KIT exon 11 (62.5%), PDGFRA D842V (25%), or SDH (12.5%) mutations, while NGS of the MM revealed BAP1 and PBRM1 alterations.

conclusionsOne in 17 GIST patients undergoing resection in this series have PM, which is significantly higher than expected if these two diseases were considered as independent events. Our results indicate that synchronous co-occurrence of GIST and PM is an underrecognized finding, suggesting a possible relationship that deserves further investigation.

Indexed as

Gastrointestinal NeoplasmsGastrointestinal Stromal TumorsMesotheliomaMesothelioma, MalignantPeritoneal NeoplasmsAgedFemaleHumansMaleMiddle AgedMutationProto-Oncogene Proteins c-kitReceptor, Platelet-Derived Growth Factor alphaRetrospective StudiesProto-Oncogene Proteins c-kitReceptor, Platelet-Derived Growth Factor alpha

Identifiers

PMID35849291
PMCPMC10226389
OpenAlexW4285726832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.