ArticleClinical research in cardiology : official journal of the German Cardiac Society2022
Clinical and echocardiographic risk factors for device-related thrombus after left atrial appendage closure: an analysis from the multicenter EUROC-DRT registry.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- An updated meta-analysis of device related thrombus following left atrial appendage closure in patients with atrial fibrillation.Frontiers in cardiovascular medicine · 2022Pooled it
- Recurrent device-related thrombosis after left atrial appendage closure with the watchman FLX: A case report and literature review.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- Antithrombotic Therapy in Percutaneous Atrial Structural Interventions.Journal of cardiovascular development and disease · 2026Review
- Left atrial appendage closure devices: a contemporary review of techniques, tips and tricks.Frontiers in cardiovascular medicine · 2026Review
- Percutaneous Left Atrial Appendage Closure: Supporting Evidence, Limitations and Future Directions.Journal of clinical medicine · 2025Review
- Epicardial Ligation of the Left Atrial Appendage in Octogenarians: Safety and Long-Term Efficacy.Journal of clinical medicine · 2025Article
- Catheter based left atrial appendage closure in-hospital outcomes in Germany from 2016 to 2020.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Impact of left atrial appendage occlusion device position on potential determinants of device-related thrombus: a patient-specific in silico study.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Timely Transesophageal Echocardiography After Left Atrial Appendage Occlusion May Avoid Delayed Detection of Device-Related Thrombus.CASE (Philadelphia, Pa.) · 2024Article
- Left Atrial Appendage Occlusion and Post-procedural Antithrombotic Management.Journal of clinical medicine · 2024Review
- Challenges and advances in device-related thrombus in left atrial appendage occlusion.Future cardiology · 2024Review
- Symptomatic vs. non-symptomatic device-related thrombus after LAAC: a sub-analysis from the multicenter EUROC-DRT registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Predictive Power for Thrombus Detection after Atrial Appendage Closure: Machine Learning vs. Classical Methods.Journal of personalized medicine · 2022Article
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Authors and funding
48 authors at 20 institutions in 9 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundData on Device-related Thrombus (DRT) after left atrial appendage closure (LAAC) remain scarce. This study aimed to investigate risk factors for DRT from centers reporting to the EUROC-DRT registry.
methodsWe included 537 patients (112 with DRT and 425 without DRT) who had undergone LAAC between 12/2008 and 04/2019. Baseline and implantation characteristics, anti-thrombotic treatment and clinical outcomes were compared between both groups in uni- and multivariate analyses. Additional propensity-score matching (PSM) was conducted to focus on the role of implantation characteristics.
resultsPatients with DRT showed higher rates of previous stroke/transient ischemic attack (TIA) (49.1% vs. 34.7%, p < 0.01), spontaneous echocardiographic contrast (SEC) (44.9% vs. 27.7%, p < 0.01) and lower left atrial appendage (LAA) peak emptying velocity (35.4 ± 18.5 vs. 42.4 ± 18.0 cm/s, p = 0.02). Occluders implanted in DRT patients were larger (25.5 ± 3.8 vs. 24.6 ± 3.5 mm, p = 0.03) and implanted deeper in the LAA (mean depth: 7.6 ± 4.7 vs. 5.7 ± 4.7 mm, p < 0.01). Coverage of the appendage ostium was achieved less often in DRT patients (69.5% vs. 81.5%, p < 0.01), while DRT patients were less frequently on oral anticoagulation (7.1% vs. 16.7%, p < 0.01). Multivariate analysis identified age, prior stroke/TIA and SEC as independent risk factors for DRT. After PSM, implantation depth was found to be predictive. Rates of stroke/TIA were higher in DRT patients (13.5% vs. 3.8%, Hazard Ratio: 4.21 [95%-confidence interval: 1.88-9.49], p < 0.01).
conclusionsDRT after LAAC is associated with adverse outcome and appears to be of multifactorial origin, depending on patient characteristics, anticoagulation regimen and device position.
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