Evidence map›Paper›PMID 35849145›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2022

Breadth and Dynamics of Human Norovirus-Specific Antibodies in the First Year of Life.

Nadja A Vielot, Amanda Brinkman, Christina DeMaso, Samuel Vilchez, Lisa C Lindesmith, Filemon Bucardo, Yaoska Reyes, Ralph S Baric, Elizabeth P Ryan, Ralph Braun and 1 more

Abstract read
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Symptomatic and Asymptomatic Norovirus Infections in Early Life; the PREVAIL Cohort, 2017-2020.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nadja A VielotDepartment of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Amanda BrinkmanTakeda Vaccines, Inc., Cambridge, Massachusetts, USA.
Christina DeMasoTakeda Vaccines, Inc., Cambridge, Massachusetts, USA.ORCID 0000-0002-2147-557X
Samuel VilchezCenter of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León, León, Nicaragua.
Lisa C LindesmithDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Filemon BucardoCenter of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León, León, Nicaragua.
Yaoska ReyesCenter of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León, León, Nicaragua.
Ralph S BaricDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
Ralph BraunTakeda Vaccines, Inc., Cambridge, Massachusetts, USA.
Sylvia Becker-DrepsDepartment of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

Antibody Landscape following Human Norovirus Infection and VaccinationR01AI148260 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S · 2020 to 2024
$3.7M
Natural history, immunity, and transmission patterns of sapovirus in a Nicaraguan birth cohortR01AI127845 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BECKER-DREPS, SYLVIA IRENE, VINJE, JAN · 2016 to 2020
$3.5M
Multi-disciplinary research training in enteric infectionsD43TW007392 · FIC · CHRISTIAN MEDICAL COLLEGE · PI KANG, GAGANDEEP · 2005 to 2020
$2.9M
Understanding protection against norovirus at the maternal-child interfaceK24AI141744 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sylvia Irene Becker-Dreps · 2019 to 2026
$1.4M
Nicaraguan Emerging and Endemic Diseases (NEED) Training ProgramD43TW010923 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BECKER-DREPS, SYLVIA IRENE · 2018 to 2023
$1.4M
FIC NIH HHS D43 TW007392FIC NIH HHS D43 TW010923FIC NIH HHS R01AI127845National Institute of Allergy and Infectious Disease R01AI148260National Institute of Allergy and Infectious DiseasesNIAID NIH HHS K24 AI141744NIAID NIH HHS R01 AI127845NIAID NIH HHS R01 AI148260
6 · The paper itself

Abstract

We measured antibody binding to diverse norovirus virus-like particles over 12 months in 16 children. All had maternal antibodies at 2 months, with estimated lowest levels at 5 months of age. Antibody increases after 3 months suggested natural infections. This information could guide the timing of future norovirus vaccines.

Indexed as

Caliciviridae InfectionsGastroenteritisNorovirusAntibodies, ViralChildHumansAntibodies, Viralacute gastroenteritisantibodiesimmunityinfantsmultiplex Luminex assaynorovirusvaccination

Identifiers

PMID35849145
PMCPMC9595050

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.