SynthesisHuman molecular genetics2022
Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Human molecular genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05638178 (The Middle Norway Corona Study - Individual and Genetic Risk Factors for COVID-19 Infection.), which is not on this map. Cited by 67 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
14.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Middle Norway Corona Study - Individual and Genetic Risk Factors for COVID-19 Infection.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Pooled it
- Expanding CIRdb, a comprehensive catalog of whole-exome sequencing data of Canary Islanders.iScience · 2026Article
- Association of ABO/Rh Blood Groups and ABO Gene VariantsViruses · 2026Article
- Article
- The role of genetic liability for psychiatric disorders and personality traits in post covid syndrome: data from three Nordic population cohorts.EClinicalMedicine · 2026Article
- European Reference Networks - a flagship activity of the EU in the field of rare and complex diseases: from 2017 to 2025.Orphanet journal of rare diseases · 2026Review
- Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON).Human genomics · 2026Article
- IFNAR2 p.F8S Variant Associates with Severe COVID-19 and Adaptive Immune Cell Activation Modulation.International journal of molecular sciences · 2026Article
- Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.Genome biology · 2026Article
- Multi-omics identifies oxidative stress, prothrombotic pathways, and lactoperoxidase variants as key factors in COVID-19 severity.EBioMedicine · 2026Article
- GWAIS-Web: a free and secure web service for ultra-fast and large-scale genome-wide association interaction studies.Bioinformatics advances · 2026Article
- Article
- SARS-CoV2 and Anti-COVID-19 mRNA Vaccines: Is There a Plausible Mechanistic Link with Cancer?Cancers · 2025Review
- Article
- Interplay among lipoprotein(a), hepatic and vascular damage in individuals with metabolic dysfunction.Cardiovascular diabetology · 2025Article
- Differential Roles of Neuro-Inflammatory Regulator, MAPK11 in Cortex and Hippocampus Following Post-Stroke Cognitive Impairments in Rats.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Genes Encoding Heat Shock Proteins Are Associated with Risk and Clinical Course of Severe COVID-19: A Pilot Study.International journal of molecular sciences · 2025Article
- Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany.Scientific reports · 2025Article
- Correlation of METTL4 genetic variants and severe pneumonia pediatric patients in Southern China.BMC genomic data · 2025Article
- Neutrophils restricted contribution ofHeliyon · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
333 authors at 20 institutions in 15 countries.
Frauke DegenhardtInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.ORCID 0000-0001-7516-3179
David EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Simonas JuzenasInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Jon Lerga-JasoInstitut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
Mareike WendorffInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Douglas Maya-MilesHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Florian Uellendahl-WerthInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Hesham ElAbdInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Malte C RühlemannInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Jatin AroraProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Onur ÖzerResearch Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Ole Bernt LenningResearch Department, Stavanger University Hospital, Stavanger, Norway.
Ronny MyhreDivision of Health Data and Digitalization, Department of Genetics and Bioinformatics (HDGB), Norwegian Institute of Public Health, Oslo, Norway.
May Sissel VadlaRandaberg Municipality, Stavanger, Norway.
Eike M WackerInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Lars WienbrandtInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Aaron Blandino OrtizDepartment of Intensive Care, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
Adolfo de SalazarIbs.Granada Instituto de Investigación Biosanitaria, Granada, Spain.
Adolfo Garrido ChercolesClinical Biochemistry Department, Osakidetza Basque Health Service, Donostialdea Integrated Health Organisation, San Sebastian, Spain.
Adriana PalomVall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain.
Agustín RuizResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Alba-Estela Garcia-FernandezDepartment of Biochemistry, University Hospital Vall d'Hebron, Barcelona, Spain.
Albert Blanco-GrauDepartment of Biochemistry, University Hospital Vall d'Hebron, Barcelona, Spain.
Alberto MantovaniIRCCS Humanitas Research Hospital, Milan, Italy.
Alberto ZanellaUniversity of Milan, Milan, Italy.
Aleksander Rygh HoltenDepartment of Acute Medicine, Oslo University Hospital, Oslo, Norway.
Alena MayerCharite Universitätsmedizin Berlin, Berlin, Germany.
Alessandra BanderaUniversity of Milan, Milan, Italy.
Alessandro CherubiniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Alessandro ProttiIRCCS Humanitas Research Hospital, Milan, Italy.
Alessio AghemoIRCCS Humanitas Research Hospital, Milan, Italy.
Alessio GerussiEuropean Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy.
Alfredo RamirezDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Alice BraunCharite Universitätsmedizin Berlin, Berlin, Germany.
Almut NebelInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Ana BarreiraLiver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Ana LleoIRCCS Humanitas Research Hospital, Milan, Italy.
Ana TelesResearch Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Anders Benjamin KildalDepartment of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø, Norway.ORCID 0000-0002-1319-6511
Andrea BiondiPediatric Departement, Centro Tettamanti-European Reference Network (ERN) PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM/Ospedale, San Gerardo, Italy.
Andrea Caballero-GarraldaBiochemistry Department, Echevarne Laboratory, Barcelona, Spain.
Andrea GannaInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Andrea GoriFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Andreas GlückKlinik für Innere Medizin I, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.
Andreas LindDepartment of Microbiology, Oslo University Hospital, Oslo, Norway.
Anja TanckInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Anke HinneyDepartment of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Anna Carreras NollaGenomes for Life-GCAT Lab, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
Anna Ludovica FracanzaniUniversity of Milan, Milan, Italy.
Anna PeschuckInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Annalisa CavalleroLaboratory of Microbiology, San Gerardo Hospital, Monza, Italy.
Anne Ma Dyrhol-RiiseInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Antonella RuelloHumanitas Gavazzeni-Castelli, Bergamo, Italy.
Antonio JuliàVall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain.ORCID 0000-0001-6064-3620
Antonio MuscatelloFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Antonio PesentiUniversity of Milan, Milan, Italy.
Antonio VozaIRCCS Humanitas Research Hospital, Milan, Italy.
Ariadna Rando-SeguraMicrobiology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Aurora SolierDepartment of Respiratory Diseases, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
Axel SchmidtInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Beatriz CortesGenomes for Life-GCAT Lab, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
Beatriz MateosCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Beatriz Nafria-JimenezClinical Biochemistry Department, Osakidetza Basque Health Service, Donostialdea Integrated Health Organisation, San Sebastian, Spain.
Benedikt SchaeferDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Innsbruck, Austria.
Björn JensenDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty Heinrich Heine University, Duesseldorf, Germany.
Carla BellinghausenDepartment of Respiratory Medicine and Allergology, University Hospital, Goethe University, Frankfurt am Main, Germany.
Carlo MajInstitute of Genomic Statistics and Bioinformatics, University Hospital Bonn, Medical Faculty University of Bonn, Bonn, Germany.
Carlos FerrandoCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Carmen de la HorraHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Carmen QueredaDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
Carsten SkurkCharite Universitätsmedizin Berlin, Berlin, Germany.
Charlotte ThibeaultCharite Universitätsmedizin Berlin, Berlin, Germany.
Chiara ScolloDepartment of Transfusion Medicine and Haematology Laboratory, San Gerardo Hospital, Monza, Italy.
Christian HerrDepartment of Internal Medicine V-Pneumology, Allergology and Intensive Care Medicine, University Hospital Saarland, Homburg, Germany.
Christoph D SpinnerDepartment of Internal Medicine II, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
Christoph GassnerInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Christoph LangeRespiratory Medicine and International Health, University of Lübeck, Lübeck, Germany.
Cinzia HuFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Cinzia PaccapeloFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Clara LehmannDepartment I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Claudio AngeliniHumanitas Clinical and Research Center, IRCCS, Milan, Italy.
Claudio CappadonaDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Clinton AzuureResearch Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
COVICAT study group, Aachen Study (COVAS)
Cristiana BiancoFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Cristina CeaDepartment of Biochemistry, University Hospital Vall d'Hebron, Barcelona, Spain.
Cristina SanchoOsakidetza Basque Health Service, Basurto University Hospital, Respiratory Service, Bilbao, Spain.
Dag Arne Lihaug HoffDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Daniela GalimbertiUniversity of Milan, Milan, Italy.
Daniele PratiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
David HaschkaDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
David JiménezDepartment of Respiratory Diseases, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
David PestañaDepartment of Anesthesiology and Critical Care, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
David ToapantaHospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain.
Eduardo Muñiz-DiazImmunohematology Department, Banc de Sang i Teixits, Autonomous University of Barcelona, Barcelona, Spain.
Elena AzzoliniIRCCS Humanitas Research Hospital, Milan, Italy.
Elena SandovalHospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain.
Eleonora BinattiEuropean Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy.
Elio ScarpiniUniversity of Milan, Milan, Italy.
Elisa T HelbigCharite Universitätsmedizin Berlin, Berlin, Germany.
Elisabetta CasaloneDepartment of Medical Sciences, Università degli Studi di Torino, Turin, Italy.
Eloisa UrrechagaOsakidetza Basque Health Service, Galdakao Hospital, Respiratory Service, Galdakao, Spain.
Elvezia Maria ParaboschiIRCCS Humanitas Research Hospital, Milan, Italy.ORCID 0000-0002-7935-798X
Emanuele PontaliDepartment of Infectious Diseases, E.O. Ospedali Galliera, Genova, Italy.
Enric ReverterHospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain.
Enrique J CalderónHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Enrique NavasDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
Erik SolligårdGeminicenter for Sepsis Research, Institute of Circulation and Medical Imaging (ISB), NTNU, Trondheim, Norway.
Ernesto ControAccident and Emergency and Emergency Medicine Unit, San Gerardo Hospital, Monza, Italy.
Eunate Arana-ArriBiocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Fátima AzizHospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain.
Federico GarciaIbs.Granada Instituto de Investigación Biosanitaria, Granada, Spain.
Félix García SánchezHistocompatibilidad y Biologia Molecular, Centro de Transfusion de Madrid, Madrid, Spain.
Ferruccio CeriottiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Filippo Martinelli-BoneschiDepartment of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, Milan, Italy.
Flora PeyvandiDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Florian KurthCharite Universitätsmedizin Berlin, Berlin, Germany.
Francesco BlasiRespiratory Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Francesco MalvestitiUniversity of Milan, Milan, Italy.
Francisco J MedranoInstituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain.
Francisco MesoneroCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Francisco Rodriguez-FriasCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Frank HansesEmergency Department, University Hospital Regensburg, Regensburg, Germany.
Fredrik MüllerInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Georg Hemmrich-StanisakInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Giacomo BellaniDepartment Emergency, Anesthesia and Intensive Care, San Gerardo Hospital, Monza, Italy.
Giacomo GrasselliUniversity of Milan, Milan, Italy.
Gianni PezzoliFondazione Grigioni per il Morbo di Parkinson and Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy.
Giorgio CostantinoUniversity of Milan, Milan, Italy.
Giovanni AlbanoHumanitas Gavazzeni-Castelli, Bergamo, Italy.
Giulia CardamoneDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Giuseppe BellelliSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Giuseppe CiterioSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Giuseppe FotiDepartment Emergency, Anesthesia and Intensive Care, San Gerardo Hospital, Monza, Italy.
Giuseppe LamorteFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Giuseppe MatulloDepartment of Medical Sciences, Università degli Studi di Torino, Turin, Italy.
Guido BaselliFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Hayato KuriharaHumanitas Clinical and Research Center, IRCCS, Milan, Italy.
Holger NebDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Ilaria MyIRCCS Humanitas Research Hospital, Milan, Italy.
Ingo KurthInstitute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Isabel HernándezResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Isabell PinkDepartment of Pneumology, Hannover Medical School, Hannover, Germany.
Itziar de RojasResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Iván Galván-FemeniaGenomes for Life-GCAT Lab, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
Jan Cato HolterInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Jan Egil AfsetOsakidetza Basque Health Service, Basurto University Hospital, Respiratory Service, Bilbao, Spain.
Jan HeyckendorfRespiratory Medicine and International Health, University of Lübeck, Lübeck, Germany.
Jan KässensInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Jan Kristian DamåsDepartment of Infectious Diseases, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Jan RybnikerDepartment I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Janine AltmüllerCologne Center for Genomics (CCG), University of Cologne, Cologne, Germany.
Javier AmpueroHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Javier MartínInstitute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.
Jeanette ErdmannInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Jesus M BanalesCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Joan Ramon BadiaRespiratory ICU, Institut Clínic Respiratory, Hospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain.
Joaquin DopazoInstituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain.ORCID 0000-0003-3318-120X
Jochen SchneiderDepartment of Internal Medicine V-Pneumology, Allergology and Intensive Care Medicine, University Hospital Saarland, Homburg, Germany.
Jonas BerganDepartment of Research, Ostfold Hospital Trust, Gralum, Norway.
Jordi BarretinaGermans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
Jörn WalterDepartment of Genetics & Epigenetics, Saarland University, Saarbrücken, Germany.
Jose Hernández QueroIbs.Granada Instituto de Investigación Biosanitaria, Granada, Spain.
Josune GoikoetxeaInfectious Diseases Service, Osakidetza, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Juan DelgadoHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Juan M GuerreroHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Julia FazaalInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Julia KraftCharite Universitätsmedizin Berlin, Berlin, Germany.
Julia SchröderInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Kari RisnesDepartment of Clinical and Molecular Medicine, NTNU, Trondheim, Norway.
Karina BanasikNovo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Karl Erik MüllerMedical Department, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
Karoline I GaedeResearch Center Borstel, BioMaterialBank Nord, Borstel, Germany.
Koldo Garcia-EtxebarriaCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Kristian TonbyInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Lars HeggelundMedical Department, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
Laura Izquierdo-SanchezCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Laura Rachele BettiniPediatric Departement, Centro Tettamanti-European Reference Network (ERN) PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM/Ospedale, San Gerardo, Italy.
Lauro SumoyGermans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
Leif Erik SanderCharite Universitätsmedizin Berlin, Berlin, Germany.
Lena J LippertCharite Universitätsmedizin Berlin, Berlin, Germany.
Leonardo TerranovaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Lindokuhle NkambuleAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Lisa KnoppDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty Heinrich Heine University, Duesseldorf, Germany.
Lise Tuset GustadGeminicenter for Sepsis Research, Institute of Circulation and Medical Imaging (ISB), NTNU, Trondheim, Norway.
Lucia GarbarinoHLA Laboratory, E.O. Ospedali Galliera, Genova, Italy.
Luigi SantoroFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Luis TéllezCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Luisa RoadeCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Mahnoosh OstadrezaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Maider IntxaustiOsakidetza Basque Health Service, Basurto University Hospital, Respiratory Service, Bilbao, Spain.
Manolis KogevinasCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Mar Riveiro-BarcielaCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Marc M BergerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Marco SchaeferStefan-Morsch-Stiftung, Birkenfeld, Germany.
Mari E K NiemiInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
María A Gutiérrez-StampaOsakidetza, OSI Donostialdea, Altza Primary Care, Biodonostia Health Research Institute, San Sebastián, Spain.
Maria CarrabbaInternal Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Maria E Figuera BassoInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Maria Grazia ValsecchiCenter of Bioinformatics, Biostatistics and Bioimaging, School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
María Hernandez-TejeroHospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain.
Maria J G T VehreschildDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt & Goethe University Frankfurt, Frankfurt am Main, Germany.
Maria ManuntaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-1875-5335
Marialbert Acosta-HerreraInstitute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.ORCID 0000-0002-9868-6535
Mariella D'AngiòPediatric Departement, Centro Tettamanti-European Reference Network (ERN) PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM/Ospedale, San Gerardo, Italy.
Marina BaldiniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Marina CazzanigaPhase 1 Research Centre, ASST Monza, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Marit M GrimsrudInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Markus CornbergDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Marta MarquiéResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID 0000-0002-0660-0950
Massimo CastoldiHumanitas Gavazzeni-Castelli, Bergamo, Italy.
Mattia CordioliInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Maurizio CecconiIRCCS Humanitas Research Hospital, Milan, Italy.
Mauro D'AmatoIkerbasque, Basque Foundation for Science, Bilbao, Spain.
Max AugustinDepartment I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Melissa TomasiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Mercè BoadaResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Michael DreherDepartment of Pneumology and Intensive Care Medicine, University Hospital Aachen, Aachen, Germany.
Michael J SeilmaierMunich Clinic Schwabing, Academic Teaching Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.
Michael JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Michael WittigInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Michela MazzoccoHLA Laboratory, E.O. Ospedali Galliera, Genova, Italy.
Michele CiccarelliHumanitas Clinical and Research Center, IRCCS, Milan, Italy.
Miguel Rodríguez-GandíaCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Monica BoccioloneHumanitas Clinical and Research Center, IRCCS, Milan, Italy.
Monica MiozzoUniversity of Milan, Milan, Italy.
Natale Imaz AyoBiocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Natalia BlayGenomes for Life-GCAT Lab, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.ORCID 0000-0002-7160-8529
Natalia ChuecaMicrobiology Unit. Hospital Universitario Clinico San Cecilio, Granada, Spain.
Nicola MontanoUniversity of Milan, Milan, Italy.
Nicole BraunInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Nicole LudwigDepartment of Human Genetics, Center of Human and Molecular Biology, University Hospital Saarland, Homburg/Saar, Germany.
Nikolaus MarxDepartment of Internal Medicine I, RWTH Aachen University Hospital, Aachen, Germany.
Nilda MartínezDepartment of Anesthesiology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
Norwegian SARS-CoV-2 Study group
Oliver A CornelyCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Oliver WitzkeDepartment of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Orazio PalmieriGastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Pa Study Group
Paola FaverioSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Paoletta PreatoniHumanitas Clinical and Research Center, IRCCS, Milan, Italy.
Paolo BonfantiSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Paolo OmodeiHumanitas Clinical and Research Center, IRCCS, Milan, Italy.
Paolo TentorioIRCCS Humanitas Research Hospital, Milan, Italy.
Pedro CastroHospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain.
Pedro M RodriguesCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Pedro Pablo EspañaOsakidetza Basque Health Service, Galdakao Hospital, Respiratory Service, Galdakao, Spain.
Per HoffmannInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Philip RosenstielInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Philipp SchommersDepartment I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Phillip SuwalskiCharite Universitätsmedizin Berlin, Berlin, Germany.
Raúl de PabloDepartment of Intensive Care, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
Ricard FerrerIntensive Care Department, Vall d'Hebron University Hospital, SODIR-VHIR research group, Barcelona, Spain.
Robert BalsDepartment of Internal Medicine V-Pneumology, Allergology and Intensive Care Medicine, University Hospital Saarland, Homburg, Germany.
Roberta GualtierottiUniversity of Milan, Milan, Italy.
Rocío Gallego-DuránHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Rosa NietoDepartment of Respiratory Diseases, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
Rossana CarpaniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Rubén MorillaHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Salvatore BadalamentiIRCCS Humanitas Research Hospital, Milan, Italy.
Sammra HaiderDepartment of Medicine, Møre & Romsdal Hospital Trust, Molde, Norway.
Sandra CiesekInstitute of Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Sandra MayInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Sara BombaceIRCCS Humanitas Research Hospital, Milan, Italy.
Sara MarsalVall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain.
Sara PigazziniInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Sebastian KleinDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Serena PelusiUniversity of Milan, Milan, Italy.
Sibylle WilflingDepartment for Infectious Diseases and Infection Control, University Hospital Regensburg, Regensburg, Germany.
Silvano BosariUniversity of Milan, Milan, Italy.
Sonja VollandHannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Søren BrunakNovo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Soumya RaychaudhuriProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Stefan SchreiberInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Stefano AlibertiIRCCS Humanitas Research Hospital, Milan, Italy.
Stephan RipkeCharite Universitätsmedizin Berlin, Berlin, Germany.
Susanne DudmanInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0001-5047-4982
Tanja WesseInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Tenghao ZhengSchool of Biological Sciences, Monash University, Clayton, VIC, Australia.
STORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task Force
Thomas BahmerKlinik für Innere Medizin I, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.
Thomas EggermannInstitute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Thomas IlligHannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Thorsten BrennerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Tomas PumarolaDepartment of Microbiology, University Hospital Vall d'Hebron, Barcelona, Spain.
Torsten FeldtDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty Heinrich Heine University, Duesseldorf, Germany.
Trine FolseraasInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Trinidad Gonzalez CejudoBiochemistry Unit, Hospital Universitario Clinico San Cecilio, Granada, Spain.
Ulf LandmesserBerlin Institute of Health, Charite Universitätsmedizin Berlin, Berlin Germany.
Ulrike ProtzerInstitute of Virology, Technical University Munich/Helmholtz Zentrum München, Munich, Germany.
Ute HehrZentrum für Humangenetik Regensburg, Regensburg, Germany.
Valeria RimoldiDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Valter MonzaniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Vegard SkogenDepartment of Infectious Diseases, University Hospital of North Norway, Tromsø, Norway.
Verena KeitelDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty Heinrich Heine University, Duesseldorf, Germany.
Verena KopfnagelHannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Vicente FriazaHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Victor AndradeDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Victor MorenoCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Wolfgang AlbrechtInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Wolfgang PeterStefan-Morsch-Stiftung, Birkenfeld, Germany.
Wolfgang PollerCharite Universitätsmedizin Berlin, Berlin, Germany.
Xavier FarreGenomes for Life-GCAT Lab, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
Xiaoli YiInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Xiaomin WangCharite Universitätsmedizin Berlin, Berlin, Germany.
Yascha KhodamoradiDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt & Goethe University Frankfurt, Frankfurt am Main, Germany.
Zehra KaradenizCharite Universitätsmedizin Berlin, Berlin, Germany.
Anna LatianoGastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Siegfried GoergInstitute of Transfusionsmedicine, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany.
Petra BacherInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Philipp KoehlerCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Florian TranInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Heinz ZollerDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Innsbruck, Austria.
Eva C SchulteInstitute of Virology, Technical University Munich/Helmholtz Zentrum München, Munich, Germany.
Bettina HeideckerCharite Universitätsmedizin Berlin, Berlin, Germany.
Kerstin U LudwigInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-8541-2519
Javier FernándezHospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain.
Manuel Romero-GómezHospital Universitario Virgen del Rocío de Sevilla, Sevilla, Spain.
Agustín AlbillosCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Pietro InvernizziEuropean Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy.
Maria ButiCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Stefano DugaIRCCS Humanitas Research Hospital, Milan, Italy.
Luis BujandaCentro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Johannes R HovInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Tobias L LenzResearch Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Rosanna AsseltaIRCCS Humanitas Research Hospital, Milan, Italy.
Rafael de CidGenomes for Life-GCAT Lab, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
Luca ValentiUniversity of Milan, Milan, Italy.
Tom H KarlsenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Mario CáceresInstitut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Humanitas University · ITUniversity of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITOslo University Hospital · NOInstituto de Salud Carlos III · ESUniversidad de Alcalá · ESUniversity of Cologne · DEIkerbasque · ESUniversitat Autònoma de Barcelona · ESUniversity of Bonn · DEAzienda Ospedaliera San Gerardo · ITConsejo Superior de Investigaciones Científicas · ESGoethe University Frankfurt · DEInnsbruck Medical University · ATInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESUniversity of Helsinki · FICharité - Universitätsmedizin Berlin · DEUniversity Hospital Schleswig-Holstein · DEBioCruces Health research Institute · ESBroad Institute · US
Funding
Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4MNIAMS NIH HHS R01 AR063759
Abstract
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
Indexed as
COVID-19Genome-Wide Association StudyHaplotypesHumansPolymorphism, GeneticSARS-CoV-2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT05638178ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.