ArticleCancer science2022
Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer.
Open access · goldAbstract read
In one paragraph
Article in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Dopamine agonist-associated fibrosis in prolactinomas: clinical challenges, impacts on the tumor microenvironment, and future directions.Frontiers in endocrinology · 2026Review
- Sodium new houttuyfonate affects tumor angiogenesis by suppressing FGF1 expression and the p38/MAPK signaling pathway in pancreatic cancer.Scientific reports · 2025Article
- HPGD induces ferroptosis and autophagy to suppress esophageal squamous cell carcinoma through the LXA4-ERK1/2-U2AF2-TFRC axis.Molecular cancer · 2025Article
- Article
- Exosome-mediated Crosstalk in the Tumor Immune Microenvironment: Critical Drivers of Hepatocellular Carcinoma Progression.Journal of clinical and translational hepatology · 2025Review
- Mechanism of 15-hydroxyprostaglandin dehydrogenase protein inhibiting cervical cancer cell proliferation through downregulation of the notch1 signaling pathway.CytoJournal · 2025Article
- The role of inflammatory factors in the tumor microenvironment of pancreatic cancer.Frontiers in immunology · 2025Review
- Research progress on cancer-associated fibroblasts in osteosarcoma.Oncology research · 2025Review
- Predictive role of HPGD gene in carcinogenesis and immune environment monitoring in human cervical cancer.Cancer biomarkers : section A of Disease markers · 2024Article
- [Role of COX-2/PGE2/EP4 Axis-induced Macrophage Functional Activation in NSCLC Development].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Article
- Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion.JHEP reports : innovation in hepatology · 2023Article
- Exosomal circRNA: emerging insights into cancer progression and clinical application potential.Journal of hematology & oncology · 2023Review
- Membrane Lipid Derivatives: Roles of Arachidonic Acid and Its Metabolites in Pancreatic Physiology and Pathophysiology.Molecules (Basel, Switzerland) · 2023Review
- Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options.World journal of gastroenterology · 2022Review
- Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer.Cancer science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 5 institutions in 2 countries.
Luke BuDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Atsuko YonemuraDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Noriko Yasuda-YoshiharaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Tomoyuki UchiharaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Galym IsmagulovDevelopmental Morphogenesis, IRCMS, Kumamoto University, Kumamoto, Japan.
Sanae TakasugiApplication Department, X-ray Division, Bruker Japan K.K., Kanagawa, Japan.
Tadahito YasudaGastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan.
Yuya OkamotoDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Fumimasa KitamuraDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Takahiko AkiyamaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kota ArimaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Rumi ItoyamaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Jun ZhangDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Lingfeng FuDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Xichen HuDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Feng WeiDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Yuichiro ArimaDevelopmental Cardiology, IRCMS, Kumamoto University, Kumamoto, Japan.
Toshiro MoroishiDepartment of Cell Signaling and Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID https://orcid.org/0000-0001-6419-3882
Koichi NishiyamaLaboratory of Vascular and Cellular Dynamics, Department of Medical Sciences, University of Miyazaki, Miyazaki City, Japan.
Guojun ShengDevelopmental Morphogenesis, IRCMS, Kumamoto University, Kumamoto, Japan.
Toshifumi MukunokiX-Earth Center, Faculty of Advanced Science and Technology Kumamoto University, Kumamoto, Japan.
Jun OtaniX-Earth Center, Faculty of Advanced Science and Technology Kumamoto University, Kumamoto, Japan.
Hideo BabaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.ORCID https://orcid.org/0000-0002-3474-2550
Takatsugu IshimotoDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.ORCID https://orcid.org/0000-0003-1852-1835
Kumamoto University · JPKumamoto University Hospital · JPKumamoto Health Science University · JPBruker (United States) · USUniversity of Miyazaki · JP
Funding
Japan Science and Technology Agency JPMJFR200HJapan Society for the Promotion of Science 20H03531Japan Society for the Promotion of Science 20K08985Japan Society for the Promotion of Science 20K09038Japan Society for the Promotion of Science 21K19535Naito FoundationThe Shinnihon Foundation of Advanced Medical Treatment Research
Abstract
The arachidonic acid cascade is a major inflammatory pathway that produces prostaglandin E
Indexed as
Pancreatic NeoplasmsVascular Endothelial Growth Factor AAnimalsArachidonic AcidCell Line, TumorDinoprostoneFibroblast Growth Factor 1FibrosisHydroxyprostaglandin DehydrogenasesMiceTumor Microenvironment15-hydroxyprostaglandin dehydrogenaseArachidonic AcidDinoprostoneFibroblast Growth Factor 1Hydroxyprostaglandin DehydrogenasesVascular Endothelial Growth Factor Acancer-associated fibroblastsprostaglandin E2tumor microenvironment
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.