Evidence map›Paper›PMID 35848620›Full record

ArticleAmerican journal of physiology. Cell physiology2022

The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca

Alicia Rivera, Joshua A Nasburg, Heesung Shim, Boris E Shmukler, Jason Kitten, Jay G Wohlgemuth, Jeffrey S Dlott, L Michael Snyder, Carlo Brugnara, Heike Wulff and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Alicia RiveraDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Joshua A NasburgDepartment of Pharmacology, School of Medicine, University of California, Davis, California.
Heesung ShimDepartment of Pharmacology, School of Medicine, University of California, Davis, California.
Boris E ShmuklerDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Jason KittenMeta Isotopes LLC, Lubbock, Texas.
Jay G WohlgemuthQuest Diagnostics, Secaucus, New Jersey.
Jeffrey S DlottQuest Diagnostics, Secaucus, New Jersey.
L Michael SnyderQuest Diagnostics, Secaucus, New Jersey.
Carlo BrugnaraDepartment of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts.
Heike WulffDepartment of Pharmacology, School of Medicine, University of California, Davis, California.
Seth L AlperDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts.ORCID 0000-0002-6228-2512
Beth Israel Deaconess Medical Center · USQuest Diagnostics (United States) · USUniversity of California, Davis · USBoston Children's Hospital · USInternational Isotopes (United States) · US

Funding

Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
NIGMS NIH HHS T32 GM099608
6 · The paper itself

Abstract

Red cell volume is a major determinant of HbS concentration in sickle cell disease. Cellular deoxy-HbS concentration determines the delay time, the interval between HbS deoxygenation and deoxy-HbS polymerization. Major membrane transporter protein determinants of sickle red cell volume include the SLC12/KCC K-Cl cotransporters KCC3/SLC12A6 and KCC1/SLC12A4, and the KCNN4/KCa3.1 Ca

Indexed as

Anemia, Sickle CellSymportersAcetic AcidAnimalsCalcimycinChloridesHEK293 CellsHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsK Cl- CotransportersMicePotassiumSolute Carrier Family 12, Member 2Acetic AcidCalcimycinChloridesIntermediate-Conductance Calcium-Activated Potassium ChannelsK Cl- CotransportersKCNN4 protein, humanKcnn4 protein, mousePotassiumSLC12A2 protein, humanSLC12A6 protein, humanSolute Carrier Family 12, Member 2SymportersbutylindazoneKCC3/SLC12A6red cellsenicapocSK4/KCa3.1/IK1/Gardos channel

Identifiers

PMID35848620
PMCPMC9448282
OpenAlexW4285728263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.