SynthesisJournal of rehabilitation medicine2022
Skeletal Muscle Changes in the First Three Months of Stroke Recovery: A Systematic Review.
Synthesis in Journal of rehabilitation medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06603701 (Follow up of Strength and Body Composition With Impedancemeter Device During the First 10 Days After Acute Stroke.), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Follow up of Strength and Body Composition With Impedancemeter Device During the First 10 Days After Acute Stroke.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of exercise-based interventions on stroke rehabilitation: an umbrella review of systematic reviews and meta-analyses.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Structural and pathophysiological muscle changes up to one year after post-stroke hemiplegia: a systematic review.European journal of physical and rehabilitation medicine · 2023Pooled it
- Targeting the muscle-brain axis to improve post-stroke cognition via the FNDC5/irisin/BDNF pathway.Journal of advanced research · 2026Article
- Corticomuscular Coherence in Post-Stroke Motor Function and Recovery.Brain sciences · 2026Article
- Mitochondrial-neuroimmune interfaces in post-stroke spasticity: from acute brain injury to chronic motor phenotypes.Frontiers in neuroscience · 2026Review
- Post-stroke sarcopenia as a neuromuscular disorder: a mini review of neural mechanisms and clinical implications.Frontiers in neurology · 2026Review
- The impact of stroke on intramuscular connective tissue in mice.Frontiers in neurology · 2026Article
- Muscle Structure and Function Recovery: Adalimumab-Calcium Channel Synergy in Post-Ischemic Stroke Sarcopenia.Journal of cachexia, sarcopenia and muscle · 2025Article
- Evaluating muscle characteristics and fall events: insights from real-world longitudinal data.Annals of medicine · 2025Article
- A Higher Charlson Comorbidity Index Is a Risk Factor for Hip Fracture in Older Adults During Low-Temperature Periods: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
- Association Between Early Mobilization and Functional Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Multicenter Retrospective Propensity Score-Matched Study.Neurocritical care · 2024Article
- Article
- Current Trends in Balance Rehabilitation for Stroke Survivors: A Scoping Review of Experimental Studies.International journal of environmental research and public health · 2023Article
- Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?Nutrients · 2023Review
- Characterization of the Structural and Mechanical Changes of the Biceps Brachii and Gastrocnemius Muscles in the Subacute and Chronic Stage after Stroke.International journal of environmental research and public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRehabilitation is important in the first months after a stroke for recovery of functional ability, but it is also challenging, since distinct recovery trajectories are seen. Therefore, studying the early changes in muscle characteristics over time (e.g. muscle strength, muscle mass and muscle volume), which are known to be associated with functional abilities, may deepen our understanding of underlying recovery mechanisms of stroke survivors.
objectiveThis systematic review aims to describe the longitudinal changes in skeletal muscles, including muscle strength, muscle mass and muscle volume, during the first 3 months post-stroke.
methodsElectronic searches were conducted in Medline, Scopus and CENTRAL. Longitudinal cohort studies or controlled interventional trials that report data about patients in the first 3 months after stroke were identified. Skeletal muscle characteristics should be measured at least twice within 3 months post-stroke by objective, quantitative assessment methods (e.g. dynamometry, ultrasound, computed tomography). Effect sizes were calculated as Hedges' g using standardized mean differences.
resultsA total of 38 studies (1,097 subjects) were found eligible. Results revealed an mean increase on the paretic side for upper and lower limb muscle strength (small to moderate effect sizes), whereas muscle thickness decreased (moderate to large effect sizes). Similar, but smaller, effects were found on the non-paretic side. There were insufficient data available to draw conclusions about lean muscle mass and muscle cross-sectional area. No studies aimed at investigating distinct trajectories of the muscle changes.
conclusionMuscle strength and thickness changes during the first 3 months after stroke in both the paretic and non-paretic side. Future studies should aim to understand "how" the stroke-induced muscle strength changes are achieved. Exploring existing data from longitudinal studies, by using cluster analyses, such as pattern recognition, could add to the current knowledge-base.
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Registered trials
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