Evidence map›Paper›PMID 35848281›Full record

ArticleDevelopment, growth & differentiation2022

Engagement of Foxh1 in chromatin regulation revealed by protein interactome analyses.

Jeff Jiajing Zhou, Paula Duyen Pham, Han Han, Wenqi Wang, Ken W Y Cho

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development, growth & differentiation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Foxh1 is a locus-specific PRC2 recruiter governing germ layer silencing.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jeff Jiajing ZhouDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Paula Duyen PhamDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Han HanDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Wenqi WangDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Ken W Y ChoDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.ORCID https://orcid.org/0000-0001-7282-1770
University of California, Irvine · US

Funding

Regulation and function of the Hippo pathway in growth controlR01GM126048 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Wenqi Wang · 2018 to 2026
$3.0M
Zygotic Genome Activation by Maternal Transcription Factors and Epigenetic ModifiersR35GM139617 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ken W.Y. Cho · 2021 to 2026
$2.6M
Mechanisms of Foxh1 pioneer factor action during mesendoderm developmentR01GM126395 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHO, KEN W.Y. · 2017 to 2020
$1.6M
American Cancer Society RSG-18-009-01-CCGNational Science Foundation 1755214NIGMS NIH HHS R01 GM126048NIGMS NIH HHS R01 GM126395NIGMS NIH HHS R35 GM139617NIH HHS R01GM126048NIH HHS R01GM126395NIH HHS R35GM139617
6 · The paper itself

Abstract

Early embryonic cell fates are specified through coordinated integration of transcription factor activities and epigenetic states of the genome. Foxh1 is a key maternal transcription factor controlling the mesendodermal gene regulatory program. Proteomic interactome analyses using FOXH1 as a bait in mouse embryonic stem cells revealed that FOXH1 interacts with PRC2 subunits and HDAC1. Foxh1 physically interacts with Hdac1, and confers transcriptional repression of mesendodermal genes in Xenopus ectoderm. Our findings reveal a central role of Foxh1 in coordinating the chromatin states of the Xenopus embryonic genome.

Indexed as

ChromatinForkhead Transcription FactorsGene Expression Regulation, DevelopmentalXenopus ProteinsAnimalsMiceProteomicsXenopus laevisChromatinForkhead Transcription FactorsFoxh1 protein, mouseFOXH1 protein, XenopusXenopus ProteinsepigeneticsHDACpioneer transcription factorsPRC2proteomicsXenopus

Identifiers

PMID35848281
PMCPMC9474667
OpenAlexW4285726240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.