Evidence map›Paper›PMID 35848094›Full record

ArticleThe International journal of eating disorders2022

Differential comorbidity profiles in avoidant/restrictive food intake disorder and anorexia nervosa: Does age play a role?

P Evelyna Kambanis, Stephanie G Harshman, Megan C Kuhnle, Danielle L Kahn, Melissa J Dreier, Kristine Hauser, Meghan Slattery, Kendra R Becker, Lauren Breithaupt, Madhusmita Misra and 4 more

Abstract read
In one paragraph

Article in The International journal of eating disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

P Evelyna KambanisDepartment of Psychology, University of Wyoming, Laramie, Wyoming, USA.
Stephanie G HarshmanEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
Megan C KuhnleEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
Danielle L KahnEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
Melissa J DreierDepartment of Psychology, University of Wyoming, Laramie, Wyoming, USA.
Kristine HauserNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Meghan SlatteryNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kendra R BeckerEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-8946-9977
Lauren BreithauptEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-2439-6519
Madhusmita MisraDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9405-2981
Nadia MicaliDepartment of Psychiatry, University of Geneva, Geneva, Switzerland.
Elizabeth A LawsonNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kamryn T EddyEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-1586-0930
Jennifer J ThomasEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-2601-581X

Funding

Homeostatic and Hedonic Food Motivation Underlying Eating Disorder TrajectoriesR01MH103402 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, LAWSON, ELIZABETH AUSTEN · 2014 to 2018
$3.7M
Neurobiological and Behavioral Risk Mechanisms of Youth Avoidant/Restrictive Eating TrajectoriesR01MH108595 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN, MICALI, NADIA · 2016 to 2020
$3.4M
The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative EmotionsK23MH125143 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BECKER, KENDRA R · 2021 to 2025
$1.1M
Neurobiology of avoidant/restrictive eating in youthK24MH120568 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2019 to 2023
$961k
NIMH NIH HHS K23 MH125143NIMH NIH HHS K23MH125143NIMH NIH HHS K24 MH120568NIMH NIH HHS K24MH120568NIMH NIH HHS R01 MH103402NIMH NIH HHS R01MH103402NIMH NIH HHS R01 MH108595NIMH NIH HHS R01MH108595
6 · The paper itself

Abstract

objectiveResearch comparing psychiatric comorbidities between individuals with avoidant/restrictive food intake disorder (ARFID) and anorexia nervosa (AN) is limited. ARFID often develops in childhood, whereas AN typically develops in adolescence or young adulthood. Understanding how age may impact differential psychological comorbidity profiles is important to inform etiological conceptualization, differential diagnosis, and treatment planning. We aimed to compare the lifetime frequency of psychiatric comorbidities and suicidality between females with ARFID (n = 51) and AN (n = 40), investigating the role of age as a covariate.

methodWe used structured interviews to assess the comparative frequency of psychiatric comorbidities/suicidality.

resultsWhen age was omitted from analyses, females with ARFID had a lower frequency of depressive disorders and suicidality compared to AN. Adjusting for age, only suicidality differed between groups. DISCUSSION: This is the first study to compare comorbidities in a similar number of individuals with ARFID and AN, and a structured clinical interview to confer ARFID and comorbidities, covarying for age, and the first to compare suicidality. Although suicidality is at least three times less common in ARFID than AN, observed differences in other psychiatric comorbidities may reflect ARFID's relatively younger age of presentation compared to AN. PUBLIC SIGNIFICANCE: Our results highlight that, with the exception of suicidality, which was three times less common in ARFID than AN irrespective of age, observed differences in psychiatric comorbidities in clinical practice may reflect ARFID's younger age at clinical presentation compared to AN.

Indexed as

Anorexia NervosaAvoidant Restrictive Food Intake DisorderFeeding and Eating DisordersAdolescentAdultComorbidityEatingFemaleHumansRetrospective StudiesYoung Adultanorexia nervosaanxiety, obsessive-compulsive, and trauma-related disordersavoidant/restrictive food intake disorderdepressive and bipolar-related disordersfeeding and eating disordersneurodevelopmental, disruptive, and conduct disorderspsychiatric comorbiditiesstructured clinical interviewsuicidality

Identifiers

PMID35848094
PMCPMC10189899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.