Evidence map›Paper›PMID 35847970›Full record

ArticleFrontiers in molecular biosciences2022

Losac and Lopap Recombinant Proteins from

Angela María Alvarez, Miryam Paola Alvarez-Flores, Carlos DeOcesano-Pereira, Mauricio Barbugiani Goldfeder, Ana Marisa Chudzinski-Tavassi, Vanessa Moreira, Catarina Teixeira

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Venom-Derived Proteins fromInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Angela María AlvarezCentre of Excellence in New Target Discovery -CENTD-, Butantan Institute, São Paulo, Brazil.
Miryam Paola Alvarez-FloresCentre of Excellence in New Target Discovery -CENTD-, Butantan Institute, São Paulo, Brazil.
Carlos DeOcesano-PereiraCentre of Excellence in New Target Discovery -CENTD-, Butantan Institute, São Paulo, Brazil.
Mauricio Barbugiani GoldfederCentre of Excellence in New Target Discovery -CENTD-, Butantan Institute, São Paulo, Brazil.
Ana Marisa Chudzinski-TavassiCentre of Excellence in New Target Discovery -CENTD-, Butantan Institute, São Paulo, Brazil.
Vanessa MoreiraCentre of Excellence in New Target Discovery -CENTD-, Butantan Institute, São Paulo, Brazil.
Catarina TeixeiraCentre of Excellence in New Target Discovery -CENTD-, Butantan Institute, São Paulo, Brazil.
Instituto Butantan · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pursuit of better therapies for disorders creating deficiencies in skeletal muscle regeneration is in progress, and several biotoxins are used in skeletal muscle research. Since recombinant proteins derived from Lonomia obliqua bristles, recombinant Lonomia obliqua Stuart-factor activator (rLosac) and recombinant Lonomia obliqua prothrombin activator protease (rLopap) act as cytoprotective agents and promote cell survival, we hypothesize that both rLosac and rLopap favour the skeletal muscle regeneration process. In the present work, we investigate the ability of these recombinant proteins rLosac and rLopap to modulate the production of key mediators of the myogenic process. The expression of myogenic regulatory factors (MRFs), cell proliferation, the production of prostaglandin E2 (PGE

Indexed as

differentiationinflammationmyoblastproliferationprostaglandin E2

Identifiers

PMID35847970
PMCPMC9280836
OpenAlexW4283761702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.